ArticleNature communications2026
High-throughput engineering of bispecific antibodies to enhance macrophage-mediated cytotoxicity of B-cell lymphoma.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Macrophages are critical effectors of antibody therapies for lymphoma, but the best targets to engage their function remain unknown. Here, we develop a 'tactical surfaceome profiling' strategy to define a comprehensive repertoire of surface antigens on B-cell lymphoma that can be targeted with antibodies to provoke macrophage attack. Across both mouse and human systems, we identify multiple unappreciated targets of opsonization as well as putative immune checkpoints. We incorporate this information into a high-throughput engineering strategy, creating 156 bispecific antibodies and identifying dozens that stimulate macrophage-mediated cytotoxicity. A heterodimeric scFv-Fc format enables our approach; it is superior to conventional bispecific antibody design and offers enhanced activity while reducing developmental complexity. Among the therapeutics we create, a bispecific comprising a SIRPα decoy domain and a CD38-targeting arm (WTa2d1xCD38) exhibits maximal efficacy with reduced risk of toxicity. This bispecific stimulates robust anti-tumor responses in xenograft models of aggressive B-cell lymphoma and shows benefits over anti-CD20 antibody rituximab. Our approach can be applied to other cancers to leverage anti-tumor responses by macrophages or other immune cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.