ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2026
[Clinical features and prognosis of influenza-associated encephalopathy in children].
Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo investigate the clinical features, prognosis, and factors associated with influenza-associated encephalopathy (IAE) in children.
methodsClinical data of 186 children hospitalized with influenza and neurological symptoms at the Children's Hospital of Chongqing Medical University from January 2015 to December 2025 were retrospectively analyzed. Based on whether they met the diagnostic criteria for acute encephalopathy, patients were divided into the IAE group and the non-IAE group. Clinical manifestations, laboratory findings, neuroimaging characteristics, treatment, and outcomes were compared between the two groups.
resultsThe IAE group included 58 patients (31.2%), with seizures and persistent disturbance of consciousness as the main neurological manifestations (40 cases each, 69.0%). Compared with the non-IAE group, the IAE group had an older age at onset and higher rates of electroencephalographic and neuroimaging abnormalities (
conclusionsPediatric IAE is characterized by seizures and persistent disturbance of consciousness, with a predilection for deep brain structures and a high risk of poor prognosis. Older age and elevated serum lactate dehydrogenase are closely associated with the development of IAE.
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