Evidence map›Paper›PMID 42607887›Full record

ArticleThe Journal of biological chemistry2026

Bat-derived antimicrobial peptide MC-CATH3 Confers protection against bacterial infections via a potential ferroptosis-like death process.

Xiangjin Kong, Zhouye Xu, Jinhui Li, Zhizhen Liu, Yiyun Zhu, Zifan Ye, Shuangyu Li, Jingjing Zhang, Lei Fu, Xudong Jiao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. FAT4 loss promotes tumor growth and ferroptosis resistance in hepatocellular carcinoma via PI3K/AKT pathway activation.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiangjin KongYantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, Shandong, China; University of Chinese Academy of Sciences, Beijing, China.
Zhouye XuDepartment of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
Jinhui LiInstitute of Medical Artificial Intelligence, South China Hospital, Medical School, Shenzhen University, Shenzhen, Guangdong, China.
Zhizhen LiuYantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, Shandong, China; School of Biological Science and Technology, University of Jinan, Jinan, Shandong, China.
Yiyun ZhuDepartment of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
Zifan YeYantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, Shandong, China; Department of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
Shuangyu LiYantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, Shandong, China; University of Chinese Academy of Sciences, Beijing, China.
Jingjing ZhangYantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, Shandong, China; University of Chinese Academy of Sciences, Beijing, China.
Lei FuInstitute of Medical Artificial Intelligence, South China Hospital, Medical School, Shenzhen University, Shenzhen, Guangdong, China. Electronic address: leifu@szu.edu.cn.
Xudong JiaoYantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, Shandong, China; University of Chinese Academy of Sciences, Beijing, China. Electronic address: xdjiao@yic.ac.cn.
Yipeng WangYantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, Shandong, China; University of Chinese Academy of Sciences, Beijing, China. Electronic address: ypwang@yic.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most naturally occurring antimicrobial peptides (AMPs) exert bactericidal activity by disrupting bacterial membranes, and although alternative mechanisms have been described, AMPs associated with ferroptosis-like features in bacterial killing remain rare. Here, we identified three novel AMPs, MC-CATH1-3, from the bat Myotis chinensis. All three peptides adopt an α-helical conformation and display potent antimicrobial activity. Notably, compared with MC-CATH1/2, MC-CATH3 causes weak membrane perturbation but triggers metabolic imbalance and excessive production of reactive oxygen species, accompanied by iron-sulfur cluster damage and abnormal intracellular Fe

Indexed as

antimicrobial mechanismantimicrobial peptidecathelicidinferroptosis-like deathreactive oxygen species

Identifiers

PMID42607887
PMCPMC13579941

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.