Evidence map›Paper›PMID 42607677›Full record

ArticleImmunity2026

GPCR-Gα13 signaling regulates survival of intestinal intraepithelial CD8

Zachary M Earley, Anshul Rao, Longhui Qiu, Konrad Knöpper, Fanglue Peng, Norihide Jo, Ananya Krishnapura, Wioletta Lisicka, Hanna Taglinao, Jinping An and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Zachary M EarleyHoward Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: zach.earley@ucsf.edu.
Anshul RaoHoward Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Longhui QiuDepartment of Medicine and Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Konrad KnöpperHoward Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Fanglue PengHoward Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Norihide JoHoward Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Ananya KrishnapuraHoward Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Wioletta LisickaDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Hanna TaglinaoHoward Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Jinping AnHoward Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Ying XuHoward Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Li V YangDivision of Hematology/Oncology, Department of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, NC, USA.
Dan LiuHoward Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Mark R LooneyDepartment of Medicine and Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Jason G CysterHoward Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: jason.cyster@ucsf.edu.

Funding

MOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0M
Chemokines and Lymphoid Tissue Organization and FunctionR01AI045073 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1999 to 2023
$7.6M
Restorative practice in repairing harm and promoting safe and inclusive practices in the laboratory.T32GM136547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Adrian Erlebacher, Anita Sil · 2020 to 2026
$4.5M
Immunobiology of the normal and injured lungR35HL161241 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARK ROBERTS LOONEY · 2022 to 2026
$4.2M
Academic Rheumatology and Clinical ImmunologyT32AR079068 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jinoos Yazdany, JULIE ZIKHERMAN · 2021 to 2026
$2.5M
NHLBI NIH HHS R35 HL161241NIAID NIH HHS L70 AI186168NIAID NIH HHS R01 AI045073NIAID NIH HHS T32 AI007334NIAMS NIH HHS T32 AR079068NIGMS NIH HHS T32 GM136547
6 · The paper itself

Abstract

Intestinal intraepithelial lymphocytes (IELs), including conventional CD8αβ T resident memory (Trm) cells and unconventional CD8αα T cells, promote tissue integrity. Here, we studied the G-protein coupled receptor signals regulating IEL positioning, homeostasis, and function. Deficiency in heterotrimeric G-protein subunit Gα13 or its effector Arhgef1 caused an intestine-specific loss of all types of CD8

Indexed as

CD8-Positive T-LymphocytesGTP-Binding Protein alpha Subunits, G12-G13Intestinal MucosaIntraepithelial LymphocytesReceptors, G-Protein-CoupledAnimalsCell MovementCell SurvivalColitisCytokinesImmunologic MemoryMiceMice, Inbred C57BLMice, KnockoutRho Guanine Nucleotide Exchange FactorsSignal TransductionCytokinesGTP-Binding Protein alpha Subunits, G12-G13Receptors, G-Protein-CoupledRho Guanine Nucleotide Exchange FactorsCD8 T cellscell migrationgamma delta T cellsGPR132heterotrimeric Ga13 proteinintestineintraepithelial lymphocytetissue resident memory

Identifiers

PMID42607677
PMCPMC13588263

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.