ArticleJournal of neurosurgery. Case lessons2026
Primary denosumab therapy for a three-column pediatric cervical aneurysmal bone cyst: illustrative case.
Article in Journal of neurosurgery. Case lessons, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPediatric spinal aneurysmal bone cysts (ABCs) involving all three columns present significant surgical challenges due to high procedural morbidity and vertebral artery risks. While denosumab is utilized off-label for these aggressive lesions, its efficacy and safety in pediatric spinal cases remain insufficiently characterized. OBSERVATIONS: A 12-year-old girl with a C6 ABC and progressive myelopathy (modified Japanese Orthopaedic Association [mJOA] score 14) underwent 12 months of primary denosumab therapy. Neurological recovery was rapid, with the mJOA score improving to 17 by the 2nd month. Serial imaging confirmed centripetal ossification and indirect cord decompression, while sagittal alignment remained stable. A structured review of 33 pediatric spinal ABC cases supported the role of denosumab in achieving early clinical and radiographic stabilization. LESSONS: Denosumab serves as a viable alternative for aggressive pediatric spinal ABCs when surgical morbidity is prohibitive. However, clinicians must monitor for severe rebound hypercalcemia following treatment cessation and potential late recurrence. Long-term surveillance is mandatory to ensure metabolic safety and evaluate the durability of the ossified bone matrix. https://thejns.org/doi/10.3171/CASE26396.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.