Evidence map›Paper›PMID 42607207›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Autoantibodies neutralizing type I interferons underlie a third of cases of Chikungunya virus encephalitis or myelitis.

Vu L Tran, Adrian Gervais, Marie-Mechtilde Champeaux, Maria Paula de Souza Sampaio, Sylvie Abel, Isabelle Calmont, Mateus Santana do Rosario, Laire Schidlowski, Jordan D Simione, Pedro Augusto Alves and 10 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Vu L Tran *St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065.ORCID 0000-0001-5320-3280
Adrian Gervais *St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065.ORCID 0000-0002-1083-5787
Marie-Mechtilde ChampeauxSt. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065.ORCID 0009-0004-3568-4147
Maria Paula de Souza SampaioLaboratório de Investigação em Saúde Global e Doenças Negligenciadas, Instituto Gonçalo Moniz, Fiocruz-Bahia, Salvador 40296-710, Brazil.ORCID 0000-0002-1130-5403
Sylvie AbelCaribbean Clinical Investigation Center, INSERM 2504, University Hospital of Martinique, Fort-de-France 97200, France.
Isabelle CalmontCaribbean Clinical Investigation Center, INSERM 2504, University Hospital of Martinique, Fort-de-France 97200, France.
Mateus Santana do RosarioLaboratório de Investigação em Saúde Global e Doenças Negligenciadas, Instituto Gonçalo Moniz, Fiocruz-Bahia, Salvador 40296-710, Brazil.ORCID 0000-0001-7404-6392
Laire SchidlowskiFaculdades Pequeno Príncipe, Rebouças, Curitiba, Paraná 80230-020, Brazil.
Jordan D SimioneSt. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065.ORCID 0009-0004-9891-8633
Pedro Augusto AlvesLaboratório de Imunologia de Doenças Virais, Instituto René Rachou, Fiocruz Minas, Belo Horizonte, Minas Gerais 30190-002, Brazil.ORCID 0000-0002-9659-5621
Anne PuelSt. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065.ORCID 0000-0003-2603-0323
Paul BastardSt. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065.ORCID 0000-0002-5926-8437
Laurent AbelSt. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065.
Carolina PrandoFaculdades Pequeno Príncipe, Rebouças, Curitiba, Paraná 80230-020, Brazil.
Rafael Freitas de Oliveira Franca *Plataforma de Pesquisa em Medicina Translacional, Fundação Oswaldo Cruz-Fiocruz São Paulo, Ribeirão Preto, São Paulo 14049-900, Brazil.
Isadora Cristina de Siqueira *Laboratório de Investigação em Saúde Global e Doenças Negligenciadas, Instituto Gonçalo Moniz, Fiocruz-Bahia, Salvador 40296-710, Brazil.ORCID 0000-0002-2520-4099
André Cabié *Caribbean Clinical Investigation Center, INSERM 2504, University Hospital of Martinique, Fort-de-France 97200, France.
Aurélie Cobat *St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065.ORCID 0000-0001-7209-6257
Shen-Ying Zhang *St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065.
Jean-Laurent Casanova *St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065.ORCID 0000-0002-7782-4169

Funding

Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6M
Inborn errors of immunity in patients with life-threatening COVID-19R01AI163029 · NIAID · ROCKEFELLER UNIVERSITY · PI CASANOVA, JEAN-LAURENT, ZHANG, QIAN · 2021 to 2025
$3.7M
Agence Nationale de la Recherche (ANR) ANR-10-IAHU-01Agence Nationale de Recherches sur le Sida et les Hépatites Virales (ANRS) ANRS0629Agence Nationale de Recherches sur le Sida et les Hépatites Virales (ANRS) ANRS-23-PEPR-MIE-0007ANR AI2D ANR-22-CE15-0046ANR GENVIR ANR-20-CE93-003ANR-RHU COVIFERON Program ANR-21-RHUS-0008Fondation pour la Recherche Médicale (FRM) EQU202503020018French Ministry of Health PHRC "2009"French National Agency for Research ANR-10-LABX-62-01HHS | NIH (NIH) R01AI163029Horizon Europe HORIZON-HLTH-2024-DISEASE-08-20Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence ANR-10-LABX-62-IBEIDNCATS NIH HHS UL1 TR001866NIAID NIH HHS R01 AI163029
6 · The paper itself

Abstract

Chikungunya virus (CHIKV) infection is typically not life threatening but may, in rare cases, affect the central nervous system (CNS). In three cohorts of confirmed CHIKV cases from Martinique (French overseas territory) and Brazil (patients aged 0 to 89 y,

Indexed as

Antibodies, NeutralizingAutoantibodiesChikungunya FeverChikungunya virusInterferon Type IMyelitisAdolescentAdultAgedAged, 80 and overBrazilChildChild, PreschoolFemaleHumansInfantAntibodies, NeutralizingAutoantibodiesInterferon Type IautoantibodiesChikungunya virusencephalitismyelitistype I interferons

Identifiers

PMID42607207
PMCPMC13506031

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.