Evidence map›Paper›PMID 42607203›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Exploiting the CXCR3/CXCL10 axis overrides tumor immune suppression by enhancing immune trafficking and effector cell priming in HNSCC.

Cheyanne K Shinn, Robert Saddawi-Konefka, Catherina L Salanga, Shiruyeh Schokrpur, J Silvio Gutkind, Tracy M Handel

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Cheyanne K ShinnSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0001-5807-756X
Robert Saddawi-KonefkaMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0002-9936-1695
Catherina L SalangaSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093.
Shiruyeh SchokrpurMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0001-9441-9547
J Silvio GutkindDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0002-5150-4482
Tracy M HandelSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0002-2558-6138

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
GRADUATE TRAINING IN CELLULAR &MOLECULAR PHARMACOLOGYT32GM007752 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER, HANDEL, TRACY M · 1985 to 2023
$13.5M
Contemporary Approaches to Cancer Cell Signaling and CommunicationT32CA009523 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DONOGHUE, DANIEL J, YANG, JING · 1985 to 2025
$12.1M
Reprogramming the Tumor Immune Microenvironment with Chemokines to Potentiate Immune Oncology Treatments in Oral CancerR01DE033909 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jorge Silvio Gutkind, Tracy M Handel · 2024 to 2026
$1.8M
Exploiting the HER3-PI3K/mTOR-Immune Axis to Design Precision Immune Oncology Therapy for Head & Neck CancerF32DE029990 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SADDAWI-KONEFKA, ROBERT · 2020 to 2020
$72k
HHS | NIH | National Cancer Institute (NCI) NIH/NCI T32 CA009523HHS | NIH | National Institute of Dental and Craniofacial Research (NIDR) NIH/NIDCR F32DE029990-01HHS | NIH | National Institute of Dental and Craniofacial Research (NIDR) NIH/NIDCR R01DE033909-01HHS | NIH | National Institute of General Medical Sciences (NIGMS) 5T32GM007752-40Moores Cancer Center, UC San Diego Health (MCC) NIH 2P30CA023100NCI NIH HHS P30 CA023100NCI NIH HHS T32 CA009523NIDCR NIH HHS F32 DE029990NIDCR NIH HHS R01 DE033909NIGMS NIH HHS T32 GM007752
6 · The paper itself

Abstract

Immune-suppressive tumor microenvironments (TMEs) limit the impact of checkpoint blockade in many cancers by restricting the infiltration and activation of CD8

Indexed as

Carcinoma, Squamous CellChemokine CXCL10Head and Neck NeoplasmsReceptors, CXCR3AnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell Line, TumorHumansKiller Cells, NaturalMiceMice, Inbred C57BLT-Cell ExhaustionTumor MicroenvironmentChemokine CXCL10Cxcl10 protein, mouseCxcr3 protein, mouseReceptors, CXCR3CXCL10CXCR3immune traffickingimmunotherapytumor microenvironment

Identifiers

PMID42607203
PMCPMC13505983

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.