ReviewChemistry & biodiversity2026
Quinazolinone as Bioactive Pharmacophore: Synthesis and Biological Activities.
Review in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quinazolinone, a nitrogen-containing bicyclic system having a benzene-fused pyrimidine ring, constitutes an important organic framework that has attracted the interest of all scientists working in the pharmacological and agricultural sectors owing to its numerous biological properties. Synthetic accessibility and structural flexibility allowed this skeleton to be easily modified with certain reagents that enhance its physicochemical properties. The aim of this review is to study the structural modifications of quinazolinone by various methods, suited for controlling virulence caused by various pathogens. Synthesis of quinazolinone derivatives and their potential hybrid skeletons with different heterocyclic moieties has also been explored. Furthermore, covering its applications from the well-established field of drug discovery to its innovative potential in crop protection, cancer treatment, microbial infections, insomnia, viral diseases, and so forth, has been reviewed with a concise discussion of their structure-activity relationships (SAR). In addition, it was deduced that modifying quinazolinone with electron-donating and electron-withdrawing substituents and heterocyclic moieties had escalated their biological aptitude in comparison to the basic quinazolinone moiety. This study can direct researchers working in this field to adopt a new approach for formulating and optimizing the synthesis and therapeutic potential of quinazolinone derivatives.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.