ArticleChemistry & biodiversity2026
Amiaspochalasins I and J, Undescribed Aspochalasins with Antibacterial Activities From Aspergillus micronesiensis.
Zhaodi Wu, Wenhong Suo, Hongquan Zhang, Chunmei Chen, Yonghui Zhang, Qin Li, Xiaotian Zhang, Hucheng Zhu
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5 · Who and what moneyAuthors and funding
8 authors.
Zhaodi WuDepartment of Pharmacy, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, P. R. China.
Wenhong SuoDepartment of Pharmacy, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, P. R. China.
Hongquan ZhangDepartment of Pharmacy, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, P. R. China.
Chunmei ChenHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Yonghui ZhangHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.ORCID https://orcid.org/0000-0002-7222-2142 Qin LiHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Xiaotian ZhangHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Hucheng ZhuHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.ORCID https://orcid.org/0000-0002-6318-0091 Funding
14th ZhaoYang talent project of the second affiliated hospital of Guangzhou university of Chinese medicine ZY2026KY06National Natural Science Foundation of China 82104021Science and Technology Project of Guangzhou 2023A04J0480
6 · The paper itselfAbstract
Two undescribed aspochalasins named amiaspochalasins I and J (1 and 2), along with a known analogue named aspochalasin U (3) were isolated from the endophytic fungus Aspergillus micronesiensis. Their structures including absolute configurations were elucidated by extensive NMR data, molecular modelling studies, and electronic circular dichroism (ECD) calculations. Usually, there is a double bond at Δ
Indexed as
Anti-Bacterial AgentsAspergillusCytochalasinsDose-Response Relationship, DrugEscherichia coliMicrobial Sensitivity TestsModels, MolecularMolecular ConformationMolecular StructureSalmonella entericaStaphylococcus aureusStructure-Activity RelationshipAnti-Bacterial AgentsCytochalasinsantibacterial activitiesAspergillus micronesiensisaspochalasinsStaphylococcus aureus
Identifiers
PMID42607107
PMCPMC13480771
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