Evidence map›Paper›PMID 42607005›Full record

ArticleBlood purification2026

Changes in Central Venous Oxygen Saturation during Inpatient Hemodialysis.

Christina Hao Wang Brotman, Molly Kennelly, Charles Hull, Clara Walling, Michael Shashaty, Jesse Yenchih Hsu, Dan Negoianu, Laura M Dember

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood purification, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christina Hao Wang BrotmanRenal, Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA, christina.brotman@pennmedicine.upenn.edu.
Molly KennellyRenal, Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Charles HullRenal, Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Clara WallingRenal, Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Michael ShashatyCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Jesse Yenchih HsuCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Dan NegoianuRenal, Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Laura M DemberRenal, Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.

Funding

Macrovascular and Microvascular Response to Fluid Removal during Hemodialysis for Acute Kidney InjuryK23DK129770 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BROTMAN, CHRISTINA HAO WANG · 2021 to 2025
$1.0M
NIDDK NIH HHS K23 DK129770
6 · The paper itself

Abstract

introductionUltrafiltration during hemodialysis can precipitate intradialytic hypotension (IDH), particularly in hospitalized patients with limited cardiovascular reserves. Central venous oxygen saturation (ScvO2) is a surrogate marker of cardiac output and may provide real-time insights into hemodynamic stress during dialysis.

methodsWe analyzed data from a prospective observational study of hospitalized adults receiving intermittent hemodialysis with central venous catheters for either acute kidney injury (AKI) or end-stage kidney disease. Continuous ScvO2 was measured throughout the dialysis sessions using Crit-Line-IV. Mixed-effects models were used to characterize intradialytic ScvO2 trends, with restricted cubic splines to evaluate the associations between ScvO2 slopes, ultrafiltration rate (UFR), and IDH.

resultsDuring 204 hemodialysis sessions among 135 individual participants, ScvO2 declined during 58% of the sessions, with substantial inter-patient variability in ScvO2 slopes. Steeper negative ScvO2 slopes were associated with a higher risk of IDH across all IDH definitions, particularly among patients with AKI. Hemodialysis sessions with the steepest ScvO2 declines (defined as the bottom 25th) were associated with increased risk of requiring an intervention for hemodynamic instability, independent of UFR and pre-dialysis blood pressure (adjusted OR: 2.42, 95% CI: 1.12, 5.20). This association was enhanced in patients with AKI (adjusted OR: 5.80, 95% CI: 2.05, 16.46).

conclusionsContinuous intradialytic ScvO2 monitoring is feasible in hospitalized patients and may identify patients at higher risk of hemodynamic instability, especially among those with AKI. ScvO2 may be a useful adjunct for guiding ultrafiltration during inpatient hemodialysis.

Indexed as

Cardiac outputCentral venous oxygen saturationHemodialysisIntradialytic hypotension

Identifiers

PMID42607005
PMCPMC13686700

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.