OmpW-mediated sensing of MUC2 GalNAc contributes to the ileal tropism of Salmonella Typhi.

Chang-Kyu Yoon, Gi Young Lee, Chanmi Kim, Katharina Ribbeck, Jeongmin Song

Abstract read

In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Chang-Kyu YoonDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY, USA.

Gi Young LeeDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY, USA.

Chanmi KimDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY, USA.

Katharina RibbeckDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

Jeongmin SongDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY, USA. Electronic address: js2957@cornell.edu.

Funding

Salmonella Typhi: Enhancement of Endemic Potential through its Unique Virulence FactorsR01AI141514 · NIAID · CORNELL UNIVERSITY · PI SONG, JEONGMIN · 2019 to 2023

$3.2M

NIAID NIH HHS R01 AI141514

6 · The paper itself

Abstract

Salmonella Typhi (STy), the causative agent of typhoid fever, preferentially infects the ileum, but the basis for this preference has remained unknown. We show that STy exploits MUC2-derived monosaccharides, such as N-acetylgalactosamine (GalNAc), to upregulate invasion and target the ileum-opposite to the response of closely related S. Typhimurium (STm), whose invasion is inhibited by MUC2. Three STy-specific extracellular residues of the outer-membrane protein OmpW (K141/T142/Q193) engage GalNAc, and a periplasmic relay through the short FepE_STy, RS12510, and TonB transmits this signal to activate the master invasion regulator HilD. Mice lacking MUC2 or gut microbiota lose STy ileal tropism, which is restored by oral GalNAc-containing monosaccharides. An OmpW triple-mutant STy strain establishes a murine oral STy infection model, identifying STy-MUC2 glycan interactions as an early step of typhoid pathogenesis and a potential target for prevention.

Indexed as

bileCP: microbiologyileum preferencemicrobiotaMUC2N-acetylgalactosamineNLRC4OmpWoral mouse modelSalmonella Typhityphoid fever

Identifiers

PMID42606933

DOI10.1016/j.celrep.2026.117801

PMCPMC13640848

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.