ArticlePhysical chemistry chemical physics : PCCP2026
Quantum chemical profiling of the electronic structure and hydrolytic stability of modified ribonucleosides.
Article in Physical chemistry chemical physics : PCCP, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Chemical modifications to RNA play essential roles in regulating structure, stability, and biological function, yet a unifying physicochemical framework for understanding how these structural modifications perturb the underlying electronic landscape and influence intrinsic reactivity remains lacking. Here, we apply density functional theory to compute electronic-structure descriptors for a comprehensive set of naturally occurring modified ribonucleosides. By analyzing HOMO-LUMO gaps as measures of global electronic softness and Wiberg bond indices as local descriptors of glycosidic bond strength, we establish systematic relationships linking stereoelectronic substitution patterns and nucleobase π-conjugation to molecular reactivity and hydrolytic stability. We find that sulfur and selenium incorporation and major-groove substitutions tend to narrow HOMO-LUMO gaps and weaken glycosidic bonds, whereas C-glycosides (as in pseudouridines) confer electronic stabilization. These results reveal physical principles governing the intrinsic reactivity of modified RNA building blocks and provide a predictive framework for anticipating modification-dependent behavior relevant to RNA stability, degradation, and next-generation sequencing technologies used to characterize the epitranscriptome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.