ReviewJournal of endocrinological investigation2026
Total thyroidectomy versus limited thyroidectomy for isthmic papillary thyroid carcinoma: a systematic review and meta-analysis of oncologic outcomes and surgical morbidity.
Review in Journal of endocrinological investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
backgroundThe optimal surgery for isthmic papillary thyroid carcinoma (IPTC) remains controversial. This meta-analysis compared oncologic and complication outcomes between total (TT) and limited thyroidectomy (LT).
methodsPubMed, Embase, and Web of Science were searched up to December 2025 for retrospective cohort studies comparing TT and LT for IPTC. Outcomes were recurrence and complications. Risk ratios (RR) with 95% confidence intervals (CI) were calculated using random-effects models.
resultsEight studies comprising 1,285 patients (696 LT, 589 TT) were included. Recurrence rates were comparable (LT: 6.61% vs. TT: 4.07%; pooled RR = 1.40, 95% CI: 0.79-2.47, P = 0.25; I
conclusionIn selected patients with isthmic papillary thyroid carcinoma, limited thyroidectomy may achieve similar short-term oncologic outcomes to total thyroidectomy while reducing complications, although the available evidence remains insufficient to establish oncologic equivalence. However, given methodological limitations, these findings are hypothesis-generating and require validation through prospective studies with standardized outcome definitions and extended follow-up.
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