Evidence map›Paper›PMID 42606807›Full record

ArticleJournal of biochemical and molecular toxicology2026

Synthesis, Anticancer Evaluation, mRNA Expression Analysis, and Molecular Docking of Fluorinated Picolinamide-Benzothiazole Derivatives Against Breast Cancer-Related Genes CDK2, ERK2, and BCL2.

Nagalakshmamma Vadabingi, Venkataswamy Mallepogu, Surendra Pothuraju, Chiranjeevi Pasala, Sumithra Poreddy, Uma Maheswari Amineni, Suresh Reddy Cirandur, Balaji Meriga

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biochemical and molecular toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nagalakshmamma VadabingiDepartment of Chemistry, Sri Venkateswara University, Tirupati, India.
Venkataswamy MallepoguDepartment of Biochemistry, Sri Venkateswara University, Tirupati, India.
Surendra PothurajuDepartment of Chemistry, Vellore Institute of Technology (VIT), Vellore, India.
Chiranjeevi PasalaBioinformatics Centre, Department of Bioinformatics, SVIMS University, Tirupati, India.
Sumithra PoreddyDepartment of Chemistry, Sri Venkateswara University, Tirupati, India.ORCID https://orcid.org/0009-0004-2558-541X
Uma Maheswari AmineniBioinformatics Centre, Department of Bioinformatics, SVIMS University, Tirupati, India.
Suresh Reddy CirandurDepartment of Chemistry, Sri Venkateswara University, Tirupati, India.
Balaji MerigaDepartment of Biochemistry, Sri Venkateswara University, Tirupati, India.ORCID https://orcid.org/0000-0001-9238-5523

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study focuses on the design, synthesis, characterization, and biological evaluation of two new series of derivatives 4-(4-amino-3-fluorophenoxy)-N-methylpicolinamide (3a-e) and 2-aminobenzothiazole (5a-e) as potential antioxidant and anticancer agents. The compounds were synthesized via a one-pot condensation reaction of 4-(4-amino-3-fluorophenoxy)-N-methylpicolinamide and 2-aminobenzothiazole with various phenyl isocyanates, isothiocyanates, and sulfonamides in the presence of triethylamine at 60°C. Reaction progress was monitored by TLC, and products were purified using column chromatography. Structural elucidation was achieved using FT-IR,

Indexed as

Antineoplastic AgentsBenzothiazolesBreast NeoplasmsCyclin-Dependent Kinase 2Gene Expression Regulation, NeoplasticMitogen-Activated Protein Kinase 1Molecular Docking SimulationPicolinic AcidsProto-Oncogene Proteins c-bcl-2AntioxidantsCell Line, TumorFemaleHumansRNA, MessengerAntineoplastic AgentsAntioxidantsBCL2 protein, humanbenzothiazoleBenzothiazolesCDK2 protein, humanCyclin-Dependent Kinase 2MAPK1 protein, humanMitogen-Activated Protein Kinase 1picolinamidePicolinic AcidsProto-Oncogene Proteins c-bcl-2RNA, Messengerantioxidant activitybenzothiazolebreast cancermolecular dockingmolecular dynamics simulationpicolinamide derivatives

Identifiers

PMID42606807
PMCPMC13480355

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.