ArticleInternational microbiology : the official journal of the Spanish Society for Microbiology2026
Quinolone resistance of Pseudomonas aeruginosa isolated from hospital infections and MexAB-OprM efflux pumps.
Article in International microbiology : the official journal of the Spanish Society for Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen frequently associated with multidrug-resistant nosocomial infections. The MexAB-OprM efflux system, a member of the Resistance-Nodulation-Division (RND) family, contributes to intrinsic and acquired resistance by extruding structurally diverse antimicrobial agents, including quinolones, from the bacterial cell.
aimThis study aimed to evaluate the association between quinolone resistance phenotypes and the presence of the mexAB-oprM determinant in clinical P. aeruginosa isolates, and to assess the functional contribution of efflux activity using the inhibitor PAβN. METHODOLOGY: This cross-sectional descriptive study was performed on 55 samples of P. aeruginosa isolated from patients visiting the Martyr Zare hospital in the city of Sari, Iran. The genus and types of isolated strains were first characterized by biochemical tests. Antibiotic-resistance patterns of the strains were evaluated based on the disk diffusion method toward 13 common antibiotics and minimum inhibitory concentration (MIC) in the presence of the PAβN inhibitor of levofloxacin antibiotic-2 and ciprofloxacin. Finally, the presence of the mexAB-oprM operon was surveyed using the polymerase chain reaction (PCR) method.
resultsIn this experiment, the highest bacterial resistance was observed toward nalidixic acid (100%), ofloxacin (80.2%), and levofloxacin (74.82%) antibiotics. The lowest resistance of antibiotics was seen toward piperacillin (39.4%), meropenem (44.3%), and imipenem (48.9%). In this study, a total of 55 clinical P. aeruginosa isolates were analyzed, of which 39 (70.90%) carried the mexB determinant.
conclusionThe findings demonstrate a strong association between the presence of the mexAB-oprM determinant and elevated quinolone resistance in clinical P. aeruginosa isolates. The significant reduction in MIC values following PAβN exposure supports the contribution of RND-type efflux mechanisms to resistance. However, given the intrinsic nature of MexAB-OprM and the broad inhibitory spectrum of PAβN, these results should be interpreted as correlative rather than causative. These data underscore efflux activity as a key resistance factor and highlight the need for expression-based profiling in future mechanistic studies.
Indexed as
Identifiers
42606790What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.