Evidence map›Paper›PMID 42606707›Full record

ArticleMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents2026

Enhancement of antitumor activity through structural optimization of 2-(Benzylamino)-thieno[2,3-d]pyrimidin-4(3H)-ones.

Nazariy Pokhodylo, Kostiantyn Levchenko, Nataliya Finiuk, Yuliia Kozak, Olha Klyuchivska, Rostyslav Stoika

Abstract read
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Article in Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Nazariy PokhodyloIvan Franko National University of Lviv, Kyryla and Mefodiya Str., 6, Lviv, 79005, Ukraine. nazariy.pokhodylo@lnu.edu.ua.
Kostiantyn LevchenkoIvan Franko National University of Lviv, Kyryla and Mefodiya Str., 6, Lviv, 79005, Ukraine.
Nataliya FiniukInstitute of Cell Biology, National Academy of Sciences of Ukraine, Drahomanov Str., 14/16, Lviv, 79005, Ukraine.
Yuliia KozakInstitute of Cell Biology, National Academy of Sciences of Ukraine, Drahomanov Str., 14/16, Lviv, 79005, Ukraine.
Olha KlyuchivskaInstitute of Cell Biology, National Academy of Sciences of Ukraine, Drahomanov Str., 14/16, Lviv, 79005, Ukraine.
Rostyslav StoikaIvan Franko National University of Lviv, Kyryla and Mefodiya Str., 6, Lviv, 79005, Ukraine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We used our previously developed one-pot green trans-annulation approach involving thermally induced 1 H-tetrazole ring cleavage and in situ pyrimidine formation for synthesis of combinatorial library of substituted 2-(benzyl/phenethylamino)-thieno[2,3-/3,2-d]pyrimidin-4(3H)-ones. Scaffold selection was guided by identification of 2-(benzylamino)-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one as a highly cytotoxic lead. Biological evaluation revealed that 4c and 4b compounds exhibited the most potent and broad-spectrum cytotoxicity. 4c compound demonstrated sub-micromolar IC

Indexed as

Antineoplastic AgentsPyrimidinonesAnimalsApoptosisCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansMiceMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsPyrimidinones1H-tetrazole(5-benzylthiazol-2-yl)amideADMEAnti-leukemic activityAntiproliferative activityApoptosisDNA damage

Identifiers

PMID42606707

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.