ArticleAnnals of surgical oncology2026
Neoadjuvant Chemoimmunotherapy Versus Standard Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma.
Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Neoadjuvant Chemoimmunotherapy Versus Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma: Is it Time for a Paradigm Shift?Annals of surgical oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundThe long-term survival outcomes of neoadjuvant chemoimmunotherapy (NCIT) compared with neoadjuvant chemoradiotherapy (NCRT) for locally advanced esophageal squamous cell carcinoma (LA-ESCC) remain unclear.
methodsPatients with LA-ESCC who underwent curative esophagectomy after receiving either NCRT or NCIT between June 2007 and December 2022 were retrospectively analyzed. The patients in the NCRT group received a uniform regimen of vinorelbine and cisplatin with concurrent radiotherapy, whereas those in the NCIT group received a PD-1 inhibitor combined with chemotherapy. Pathologic outcomes, overall survival (OS), and disease-free survival (DFS) were compared between the groups before and after application of inverse probability of treatment-weighting (IPTW).
resultsOverall, 462 patients were included (232 with NCIT; 230 with NCRT). The median follow-up period was 51.5 months (interquartile range, 33.0-87.0 months). The IPTW-adjusted analyses showed higher 3-year OS with NCIT versus NCRT (79.7 vs 68.2%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.28-0.91; P = 0.023). Multiple sensitivity analyses yielded consistent results. The 3-year DFS did not differ significantly between the two groups (73.9 vs 62.7%; HR, 0.65; 95% CI 0.40-1.05; P = 0.076). Pathologic complete response rates were comparable (NCIT, 33.6% vs NCRT, 41.0%; P = 0.229). Within 2 years postoperatively, NCIT had lower rates of overall recurrence (15.8 vs 28.8; P = 0.033) and distant metastases (6.6 vs 17.0%, P = 0.006) than NCRT, whereas the locoregional recurrence rate was similar (8.7 vs 11.8%; P = 0.592).
conclusionsIn this retrospective cohort of selected patients with LA-ESCC who completed neoadjuvant therapy and underwent curative resection, NCIT was associated with better OS than NCRT.
Indexed as
Identifiers
42606652What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.