Evidence map›Paper›PMID 42606634›Full record

ArticleActa neurologica Belgica2026

miR-584-5p suppresses Aβ

Lingyan Cheng, Pingting Gong, Xiaofeng Su, Yika Fang, Tao Wang

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Article in Acta neurologica Belgica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Lingyan ChengDepartment of Neurology, China Resources & Wisco General Hospital, Wuhan University of Science and Technology, Wuhan, 430080, China.
Pingting GongDepartment of Geriatrics, Liangping District People's Hospital of Chongqing, Chongqing, 405200, China.
Xiaofeng SuThe HaiDian 11th Retreat for Demoted Cadres of Beijing Veteran Cadres Service Administration, Beijing Garrison Area, Beijing, 100091, China.
Yika FangGeriatrics Department, Shantou Central Hospital, Shantou, 515031, China.
Tao WangDepartment of Neurology, People's Hospital of Wansheng Economic and Technological Development Zone, No. 43, Wandong North Road Wansheng Economic Development Zone, Chongqing, 400800, People's Republic of China. Wangtao88126@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlzheimer's disease (AD) represents a profoundly detrimental neurodegenerative disorder, and early diagnosis coupled with effective treatment remains a major clinical challenge. MicroRNAs (miRNAs) have emerged as key regulators associated with pathological processes in AD.

aimThis study aimed to explore the expression pattern and the likely diagnostic value of miR-584-5p in AD, as well as its molecular mechanism of action in regulating β-amyloid (Aβ)-induced apoptosis.

methodsPeripheral blood samples from 90 AD patients and age- and sex-matched controls were examined using RT-qPCR. Correlation analyses of miR-584-5p expression with key AD biomarkers (Aβ

resultsmiR-584-5p was significantly downregulated in AD patients, and its expression correlated with Aβ

conclusionsmiR-584-5p exerted neuroprotective effects via the miR-584-5p/HDAC1 axis, offering new insights into AD pathogenesis and suggesting this axis as a candidate for further preclinical investigation.

Indexed as

Alzheimer's diseaseCell apoptosisHDAC1miR-584-5p

Identifiers

PMID42606634

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