Evidence map›Paper›PMID 42606356›Full record

ArticlemBio2026

Lassa fever and Argentine hemorrhagic fever treatment in guinea pigs using broad-spectrum cap-dependent endonuclease inhibitors.

Junki Maruyama, Satoshi Taniguchi, Takeshi Saito, Shintaro Yamada, Rachel A Reyna, Ruchi Paroha, Daiki Kobayashi, Gavriella Siman-Tov, Christine Click, Kirsten Littlefield and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Junki MaruyamaDepartment of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA.ORCID 0000-0003-0088-4793
Satoshi TaniguchiDepartment of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA.
Takeshi SaitoDepartment of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA.ORCID 0000-0002-6908-0702
Shintaro YamadaDepartment of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA.
Rachel A ReynaDepartment of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA.
Ruchi ParohaDepartment of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA.
Daiki KobayashiDepartment of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA.
Gavriella Siman-TovDepartment of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA.
Christine ClickDepartment of Molecular Biology and Biochemistry, The University of Texas Medical Branch, Galveston, Texas, USA.
Kirsten LittlefieldDepartment of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, USA.
Shinsuke TobaShionogi and Co Ltd, Osaka, Japan.
Yoshiyuki TaodaShionogi and Co Ltd, Osaka, Japan.
Misato ShibazakiShionogi and Co Ltd, Osaka, Japan.
Cheng HuangDepartment of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA.
Michihito SasakiDivision of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.ORCID 0000-0003-1607-2175
Yasuko OrbaDivision of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Hirofumi SawaDivision of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.ORCID 0000-0003-2569-2755
Akihiko SatoShionogi and Co Ltd, Osaka, Japan.ORCID 0000-0001-6625-1679
Slobodan PaesslerDepartment of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA.ORCID 0000-0002-2213-9551

Funding

Viral factors responsible for Lassa virus pathogenicityR00AI156012 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MARUYAMA, JUNKI · 2023 to 2024
$498k
Viral factors responsible for Lassa virus pathogenicityK99AI156012 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MARUYAMA, JUNKI · 2021 to 2022
$177k
CRDF Global JP22jk0210037CRDF Global R-202105-67761Japan Agency for Medical Research and Development JP223fa627005John S. Dunn FoundationNational Institute of Allergy and Infectious Diseases K99AI156012, R00AI156012NIAID NIH HHS K99 AI156012NIAID NIH HHS R00 AI156012The Institute for Human Infection and Immunity
6 · The paper itself

Abstract

The class

Indexed as

Antiviral AgentsEndonucleasesEnzyme InhibitorsHemorrhagic Fever, AmericanLassa FeverAnimalsDisease Models, AnimalGuinea PigsLassa virusTreatment OutcomeVirus ReplicationAntiviral AgentsEndonucleasesEnzyme Inhibitorsantiviralarenaviruscap-dependent endonucleasehemorrhagic feverJunin virusLassa virus

Identifiers

PMID42606356
PMCPMC13556185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.