Observational studyThe Journal of international medical research2026
Clinical characteristics of IgG4-related disease patients with different serum IgG4 levels: A single-center retrospective study.
Observational study in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
ObjectiveImmunoglobulin G4-related disease is a rare autoimmune disorder, and serum immunoglobulin G4 (IgG4) levels vary among patients. This study aimed to systematically compare the clinical features of patients with immunoglobulin G4-related disease across different serum IgG4 levels to improve understanding of disease heterogeneity.MethodsThis retrospective observational study enrolled 77 patients with immunoglobulin G4-related disease admitted to Yichang Central People's Hospital from January 2019 to April 2025.ResultsAmong the 77 patients with immunoglobulin G4-related disease, 13 (16.88%) had serum IgG4 levels ≤ the upper limit of normal (ULN), 19 (24.68%) had levels within the range of ULN <IgG4< 2 × ULN, 25 (32.47%) had levels within the range of 2 × ULN ≤IgG4 <5 × ULN, and 20 (25.97%) had serum IgG4 levels ≥5 × ULN. The incidence of multiorgan involvement was higher in patients with serum IgG4 levels ≥5 × ULN than in patients with serum IgG4 levels ≤ULN and those with 2 × ULN ≤IgG4 <5 × ULN (p = 0.007). Additionally, the prevalence of lymph node involvement was significantly higher in patients with serum IgG4 levels ≥5 × ULN than in those with 2 × ULN ≤IgG4 <5 × ULN (p = 0.013). Patients with serum IgG4 levels ≥5 × ULN had higher total protein (p = 0.007), globulin (p < 0.001), and immunoglobulin G (p < 0.001) levels than patients with serum IgG4 levels ≤ ULN and those with 2 × ULN ≤IgG4 <5 × ULN. They also had lower serum albumin levels than patients with 2 × ULN ≤IgG4 <5 × ULN (p
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