Evidence map›Paper›PMID 42606298›Full record

ArticlemBio2026

Secreted nuclease effector neutralization by active site mimicry in Bacillota.

Romina Abbasian, Bishal Parajuli, Liping Yu, Brice Durocher, Emma Gardner, Ethan Chodur, Maddisen K Dwelley, Craig D Ellermeier, Theresa D Ho, Dustin E Bosch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Romina Abbasian *Pathology Department, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0001-9758-5006
Bishal Parajuli *Pathology Department, University of Iowa, Iowa City, Iowa, USA.ORCID 0009-0004-9130-0144
Liping YuBiochemistry and Molecular Biology Department, University of Iowa, Iowa City, Iowa, USA.
Brice DurocherMolecular Physiology and Biophysics Department, University of Iowa, Iowa City, Iowa, USA.
Emma GardnerPathology Department, University of Iowa, Iowa City, Iowa, USA.
Ethan ChodurPathology Department, University of Iowa, Iowa City, Iowa, USA.
Maddisen K DwelleyPathology Department, University of Iowa, Iowa City, Iowa, USA.
Craig D EllermeierMicrobiology and Immunology Department, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0002-8953-5081
Theresa D HoMicrobiology and Immunology Department, University of Iowa, Iowa City, Iowa, USA.
Dustin E BoschPathology Department, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0002-7430-2939

Funding

National HTX Center: Enabling Access to State-of-the-Art Crystallization CapabilitiesR24GM141256 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Sarah Elizabeth Johnson Bowman · 2021 to 2026
$6.3M
Contact-dependent interbacterial responses modulate intestinal colonization by Bacteroides speciesK08AI159619 · NIAID · UNIVERSITY OF IOWA · PI BOSCH, DUSTIN E · 2021 to 2025
$807k
National Institute of Allergy and Infectious Diseases K08AI159619NIAID NIH HHS K08 AI159619NIGMS NIH HHS R24 GM141256
6 · The paper itself

Abstract

Polymorphic toxins mediate interbacterial antagonism among competitors in the gut microbiome. Nuclease effectors, distantly related to the type VI-secreted Bacteroidales Tde, are enriched in human gut Bacillota. Tde mediates antagonism among Bacillota, and expression of the cognate immunity, Tdi, in recipients is protective. Crystal structures of Tde/Tdi complexes from two

Indexed as

BacillotaBacterial ToxinsMolecular MimicryBacillusCatalytic DomainCrystallography, X-RayEnterococcusHumansModels, MolecularProtein BindingProtein ConformationBacterial Toxinsinterbacterial antagonismmimicrynucleasepolymorphic toxin

Identifiers

PMID42606298
PMCPMC13556189

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.