Evidence map›Paper›PMID 42606143›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Dual-Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti-Inflammatory and Anti-Fibrotic Effects.

Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hongyi ZhangDepartment of Plastic Surgery, Ear Reconstruction Institute, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0001-9164-9072
Jinwei LiDepartment of Pediatric Neurosurgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0002-4599-995X
Shan HuaDepartment of Plastic Surgery, Ear Reconstruction Institute, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Shengming WuDepartment of Plastic Surgery, Ear Reconstruction Institute, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0002-3019-3072
Chenlong HeDepartment of Plastic Surgery, Ear Reconstruction Institute, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Yuan ZhuDepartment of Plastic Surgery, Ear Reconstruction Institute, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Ming YinDepartment of Plastic Surgery, Ear Reconstruction Institute, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Han ZhouDepartment of Plastic Surgery, Ear Reconstruction Institute, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Huawei LiuDepartment of Plastic Surgery, Ear Reconstruction Institute, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, People's Republic of China.ORCID https://orcid.org/0009-0000-1083-0727
Chika HasegawaDepartment of Plastic Surgery, Ear Reconstruction Institute, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Jun LyuMassachusetts General Hospital, Harvard University, Boston, Massachusetts, USA.
Keyue XiaoDepartment of Plastic Surgery, Ear Reconstruction Institute, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Hua JiangDepartment of Plastic Surgery, Ear Reconstruction Institute, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Yilong WangDepartment of Plastic Surgery, Ear Reconstruction Institute, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0001-7483-9296
Yuxin QianDepartment of Plastic Surgery, Ear Reconstruction Institute, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.

Funding

East Hospital affiliated to Tongji University introduced talent research startup Fund DFRC2019008Featured Clinical Discipline Project of Shanghai Pudong Fund PWYts2021-07Featured Department Foundation of Shanghai East Hospital 2024-DFTS-007National Natural Science Foundation of China 32271439Postdoctoral Fellowship Program of CPSF GZC20251497
6 · The paper itself

Abstract

During skin wound healing, complex interactions among multiple cell types and dynamic phase evolution make it difficult for biomaterial scaffolds to balance late-healing and over-healing, often resulting in delayed wound healing, persistent inflammatory responses, and hypertrophic scars due to spatiotemporal mismatch. Precise regulation of fibroblast-to-myofibroblast transformation and macrophage polarization is therefore essential yet challenging. Fibroblast activation protein (FAP) has been identified as a key bio-cue in pulmonary and hepatic fibrosis, but whether FAP-targeting peptide (FTP) within a biomimetic system can address this dilemma remains unclear. Here, a methacrylated hyaluronic acid hydrogel microneedle patch (CAF@MN) integrating a dual-targeting biomimetic nanozyme system (Cu-CeO

Indexed as

anti‐fibrosisfibroblast activation proteininflammationnanozymesskin wound healing

Identifiers

PMID42606143
PMCPMC13479856

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.