Dual-Responsive Hydrogels Integrate Bioelectrical Stimulation and Piezo-Photocatalysis for Regenerative Treatment of Infected Wounds.

Infected wounds represent a formidable clinical challenge, as persistent bacterial colonization and disrupted bio-signaling collectively hinder effective tissue repair. Conventional passive dressings lack the capacity to actively modulate this complex microenvironment. Here, we report a wireless, dual-responsive hydrogel (PVA/P(VDF-TrFE)/BiOClBr@PDA, PPBP) based on porous poly(vinyl alcohol) (PVA), piezoelectric poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)), and polydopamine-modified bismuth oxybromide chloride (BiOClBr@PDA). The constructed hydrogel orchestrates piezoelectric stimulation and piezo-photocatalysis to simultaneously eradicate infection and accelerate tissue regeneration. Under concurrent ultrasonic and optical stimulation, this platform efficiently transduces mechanical and light energy into therapeutic electrical cues and reactive oxygen species (ROS). This dual-mode activation enables enhanced antibacterial efficacy against diverse bacterial strains, significantly outperforming single-mode treatments while maintaining favorable biocompatibility. In an infected wound model, the constructed composite hydrogel PPBP effectively inhibits bacteria and attenuates inflammatory responses via controlled ROS generation, while piezoelectric stimulation supports re-epithelialization and collagen deposition. Together, these effects promote accelerated and structurally improved wound healing. This work establishes a paradigm for utilizing multi-source energy-responsive hydrogels as an active strategy for regulating infected wound environments and supporting functional skin regeneration.