ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Electrochemically Driven Regioselective Radical Functionalization of Allenes: Scope and Mechanistic Insights.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Despite their rich reactivity and unique cumulated π-system, allenes remain largely untapped platforms in electrochemical radical functionalizations. Herein, we report a regioselective electrochemical protocol that merges radical addition with anodic oxidative cyclization, enabling the construction of oxazoline and oxazolidine-2-imine frameworks under mild and sustainable conditions. Detailed mechanistic investigations along with DFT computational studies were carried out to probe the reaction pathway. These studies suggested selective radical addition at the central allenic carbon, forming an allyl radical intermediate that undergoes anodic oxidation and intramolecular nucleophilic cyclization, enabling efficient access to functionalized heterocyclic derivatives without external oxidants. This work unveils a new paradigm for electrochemically driven allene functionalization, expanding the scope of radical-mediated electroorganic synthesis toward biologically relevant moieties.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.