Evidence map›Paper›PMID 42605684›Full record

ArticleStroke2026

Thrombus Perviousness Is Associated With Differential Treatment Outcomes Following IVT and EVT in MeVO Stroke.

Mingchen Zhang, Xiaoyu Wu, Yang Qu, Jiale Zhang, Wenbo Jia, Yifei Zhang, Siyuan Wang, Zhen-Ni Guo, Hang Jin

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In one paragraph

Article in Stroke, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Mingchen Zhang *Department of Neurology, Stroke Center, The First Hospital of Jilin University, China (M.Z., X.W., Y.Q., J.Z., W.J., Y.Z., S.W., Z.-N.G., H.J.).ORCID 0009-0007-3201-0210
Xiaoyu Wu *Department of Neurology, Stroke Center, The First Hospital of Jilin University, China (M.Z., X.W., Y.Q., J.Z., W.J., Y.Z., S.W., Z.-N.G., H.J.).ORCID 0009-0002-5002-8645
Yang QuDepartment of Neurology, Stroke Center, The First Hospital of Jilin University, China (M.Z., X.W., Y.Q., J.Z., W.J., Y.Z., S.W., Z.-N.G., H.J.).
Jiale ZhangDepartment of Neurology, Stroke Center, The First Hospital of Jilin University, China (M.Z., X.W., Y.Q., J.Z., W.J., Y.Z., S.W., Z.-N.G., H.J.).
Wenbo JiaDepartment of Neurology, Stroke Center, The First Hospital of Jilin University, China (M.Z., X.W., Y.Q., J.Z., W.J., Y.Z., S.W., Z.-N.G., H.J.).
Yifei ZhangDepartment of Neurology, Stroke Center, The First Hospital of Jilin University, China (M.Z., X.W., Y.Q., J.Z., W.J., Y.Z., S.W., Z.-N.G., H.J.).
Siyuan WangDepartment of Neurology, Stroke Center, The First Hospital of Jilin University, China (M.Z., X.W., Y.Q., J.Z., W.J., Y.Z., S.W., Z.-N.G., H.J.).
Zhen-Ni GuoDepartment of Neurology, Stroke Center, The First Hospital of Jilin University, China (M.Z., X.W., Y.Q., J.Z., W.J., Y.Z., S.W., Z.-N.G., H.J.).ORCID 0000-0002-8922-3862
Hang JinDepartment of Neurology, Stroke Center, The First Hospital of Jilin University, China (M.Z., X.W., Y.Q., J.Z., W.J., Y.Z., S.W., Z.-N.G., H.J.).ORCID 0009-0000-4621-3229

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn acute ischemic stroke due to medium vessel occlusion, the relative effectiveness of intravenous thrombolysis (IVT) and endovascular therapy (EVT) remains controversial, and treatment benefits may vary across patients. We evaluated the interaction between thrombus perviousness and treatment modality on 90-day functional outcome in patients with medium vessel occlusion.

methodsThis single-center retrospective cohort study analyzed 255 patients with imaging-confirmed medium vessel occlusion treated at a stroke center in China between 2018 and 2024 (154 IVT and 101 EVT with or without prior IVT). Thrombus perviousness was quantified using the thrombus perviousness index (TPI) from noncontrast computed tomography and computed tomography angiography. Multivariable logistic regression and inverse probability of treatment weighting evaluated the TPI-by-treatment interaction for 90-day functional independence (modified Rankin Scale score ≤2). Sensitivity analyses used alternative weighting strategies and a surrogate thrombus perviousness measure.

resultsThe 90-day functional independence rate was similar between the IVT and EVT groups (51.9% versus 51.5%;

conclusionsIn medium vessel occlusion, thrombus perviousness was associated with treatment outcomes, with higher perviousness favoring IVT-related benefits, whereas the use of EVT may be relatively advantageous in patients with low-perviousness thrombi.

Indexed as

Endovascular ProceduresIschemic StrokeThrombolytic TherapyThrombosisAgedFemaleFibrinolytic AgentsHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeFibrinolytic Agentsendovascular procedureshemorrhageischemic strokethrombosistreatment outcome

Identifiers

PMID42605684
PMCPMC13619136

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.