ArticleChemical biology & drug design2026
Multi-Omics Integration Identifies PTGS2 as a Candidate Diagnostic Biomarker and Precise Therapeutic Target Related to Schisandra chinensis for Osteoarthritis.
Article in Chemical biology & drug design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Currently, there is a lack of effective disease-modifying drugs for osteoarthritis (OA), and existing treatment methods often accompany significant adverse reactions. Schisandra chinensis (SC), as a traditional Chinese medicine with anti-inflammatory activity, may have therapeutic potential for OA, but its specific molecular mechanism is not yet clear. This study adopts network pharmacology strategy to explore the potential mechanism of SC intervention in OA. Screen SC active ingredients through TCMSP database and obtain OA-related targets by combining OMIM, TTD, and GeneCards databases. Venn analysis shows that there are only 5 common targets between SC and OA; Further analysis revealed that PTGS2 is the only candidate target with diagnostic value (AUC = 0.702, p = 0.015), while AR, ESR1, DPP4, and CHRM2 did not show clinical diagnostic efficacy. Functional enrichment analysis suggests that common targets mainly involve steroid hormone responses and extracellular matrix (ECM) related pathways, with a significant enrichment in "response to steroid hormones" (adjusted p = 1.2 × 10
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