Evidence map›Paper›PMID 42605598›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2026

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase.

Shiyao Song, Yan-Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma and 5 more

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In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shiyao SongDepartment of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Yan-Lai TangDepartment of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Xiaoting LiuDepartment of Gastrointestinal Surgery, School of Medicine, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen, Fujian, China.
Jiayi ZhengGuangdong Provincial Key Laboratory of Plant Resources Biorefinery, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China.
Chong WuDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Tang LiGuangdong Provincial Key Laboratory of Plant Resources Biorefinery, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China.
Junhong YeGuangdong Medical University Affiliated Hospital, Guangdong Medical University, Zhanjiang, Guangdong, China.
Dianmin XiaDepartment of Oncology, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, China.
Yong MeiDepartment of Hepatobiliary Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Jingxuan MaWest China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
Libin HuangDepartment of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Xuequn LuoDepartment of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Liheng ChenGuangdong Provincial Key Laboratory of Plant Resources Biorefinery, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China.
Yanlin QinGuangdong Provincial Key Laboratory of Plant Resources Biorefinery, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China.
Weiling HeDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0009-0007-1656-6892

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2021A1515111169Basic and Applied Basic Research Foundation of Guangdong Province 2021B1515230009Basic and Applied Basic Research Foundation of Guangdong Province 2024A1515030129Guangdong Provincial Key Areas R&D Programs of "Precision medicine and stem cells" 2023B1111020005National Key Research And Development Plan 2022YFC3401000National Natural Science Foundation of China 22378076National Natural Science Foundation of China 82472087National Natural Science Foundation of China 92359302Natural Science Foundation for Outstanding Youth Team Project of Guangdong Province 2024B1515040030
6 · The paper itself

Abstract

FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers. However, the issues of excessive toxicity and prolonged treatment cycles persist. To address this limitation, we developed a novel methylated amino acid-modified lignin inspired by biological methylation, creating a pH-responsive charge-reversal drug delivery system for FOLFOX chemotherapy. This system stabilizes thymidylate synthase (TS) and combines with deoxyuridine monophosphate (dUMP) to demonstrate significantly improved therapeutic outcomes of FOLFOX against colorectal cancer (CRC). The FOLFOX-loaded nanodrug showed targeted antitumor activity against CRC and induced tumor cell death through multiple mechanisms, including apoptosis, necrosis, cell cycle regulation, DNA damage, and reactive oxygen species generation. Furthermore, the nano-formulation activated immune responses to enhance chemotherapeutic potency and effectively reducing renal toxicity associated with chemotherapy drugs. These findings suggest that protein methylation-mimicked lignin could be a valuable addition to current first-line chemotherapy options and holds promise for enhancing chemotherapy against solid tumors.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsDrug CarriersLigninThymidylate SynthaseAnimalsAntineoplastic AgentsApoptosisCell Line, TumorColorectal NeoplasmsFluorouracilHumansLeucovorinMethylationMiceOrganoplatinum CompoundsReactive Oxygen SpeciesAntineoplastic AgentsDrug CarriersFluorouracilLeucovorinLigninOrganoplatinum CompoundsReactive Oxygen SpeciesThymidylate Synthasecharge reversalcolorectal cancerFOLFOXligninnanoparticles

Identifiers

PMID42605598
PMCPMC13660821

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.