Evidence map›Paper›PMID 42605542›Full record

ArticleDiabetes, obesity & metabolism2026

Polyendocrine Metabolic Ovarian Syndrome and the Entire Spectrum of Gestational Dysglycemia: A Population-Based Cohort Study.

Yulia Balmakov, Maya Nitecki, Hertzel C Gerstein, Orit Pinhas-Hamiel, Gabriel Chodick, Estela Derazne, Yael Barer, Noah Gruber, Aya Bardugo, Cole D Bendor and 5 more

Abstract read
In one paragraph

Article in Diabetes, obesity & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yulia BalmakovDepartment of Military Medicine, Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem, Israel.
Maya NiteckiDepartment of Military Medicine, Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem, Israel.
Hertzel C GersteinDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.ORCID https://orcid.org/0000-0001-8072-2836
Orit Pinhas-HamielSchool of Medicine, The Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Gabriel ChodickDepartment of Epidemiology and Preventive Medicine, School of Public Health, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.ORCID https://orcid.org/0000-0002-5189-8995
Estela DerazneSchool of Medicine, The Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Yael BarerDepartment of Epidemiology and Preventive Medicine, School of Public Health, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Noah GruberSchool of Medicine, The Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Aya BardugoDepartment of Military Medicine, Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem, Israel.
Cole D BendorDepartment of Military Medicine, Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem, Israel.
Avi ShinaDepartment of Military Medicine, Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem, Israel.
Arnon AfekThe Dina Recanati School of Medicine, Reichman University, Herzliya, Israel.
Tali Cukierman-YaffeDepartment of Epidemiology and Preventive Medicine, School of Public Health, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.ORCID https://orcid.org/0000-0003-1289-5633
Gilad TwigDepartment of Epidemiology and Preventive Medicine, School of Public Health, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.ORCID https://orcid.org/0000-0003-2829-3645
Adi VinogradDepartment of Epidemiology and Preventive Medicine, School of Public Health, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.ORCID https://orcid.org/0000-0002-1527-8473

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsEvaluating the association between polyendocrine metabolic ovarian syndrome (PMOS), traditionally termed polycystic ovary syndrome, and the broad spectrum of gestational dysglycemia in a large, universally screened population. MATERIALS AND

methodsThis retrospective cohort study used routinely collected data linked from Israeli military pre-recruitment medical evaluation (ages 16-19) and Maccabi Healthcare Services electronic health records, including two-step GDM screening during the first pregnancy, 2001-2019. Outcome was categorised into gestational normoglycemia, abnormal glucose challenge test (GCT) with a normal oral glucose tolerance test (OGTT), gestational impaired glucose tolerance (GIGT) and gestational diabetes mellitus (GDM). Multivariable logistic models were adjusted for birth year, adolescent BMI, socioeconomic position, country of birth, cognitive performance, education and age at GDM screening.

resultsAmong 177 241 women, 13 648 (7.7%) had PMOS. Rates (95% CI) of abnormal GCT with normal OGTT, GIGT, GDM and any dysglycemia were 9.1% (8.6-9.6) versus 7.9% (7.8-8.0), 4.9% (4.5-5.3) versus 4.0% (3.9-4.1), 6.3% (5.9-6.7) versus 4.2% (4.1-4.3) and 20.3% (19.6-21.0) versus 16.1% (16.0-16.3) among women with versus without PMOS, respectively. Corresponding adjusted ORs (95% CI) were 1.18 (1.11-1.26), 1.26 (1.16-1.37), 1.61 (1.49-1.73) and 1.31 (1.25-1.37), respectively. An interaction was observed with the highest odds among women with both PMOS and high adolescent BMI (adjusted OR 1.77, 95% CI: 1.52-2.10).

conclusionsWomen with PMOS, and particularly those with concomitantly high BMI, constitute a high-risk subgroup for subthreshold gestational dysglycemia and GDM, highlighting the importance of pre-pregnancy mitigation of modifiable risk factors.

Indexed as

Diabetes, GestationalMetabolic SyndromePolycystic Ovary SyndromeAdolescentAdultCohort StudiesFemaleGlucose Tolerance TestHumansIsraelPregnancyRetrospective StudiesRisk FactorsYoung Adultbody mass indexgestational diabetes mellituspolyendocrine metabolic ovarian syndromepregnancysubthreshold gestational dysglycemia

Identifiers

PMID42605542
PMCPMC13646381

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.