Evidence map›Paper›PMID 42605530›Full record

Trial reportClinical pharmacology in drug development2026

Bioequivalence Study of Two Ibuprofen Arginine Formulations in Healthy Chinese Subjects Under Fed Conditions.

Yiyang Ying, Chunqi Huang, Li Xu, Yi Wu, Shufan Cai, Lijun Ye, Xiangxin Huang, Lin Wang, Ying Wang

Abstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical pharmacology in drug development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yiyang YingThe First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
Chunqi HuangDepartment of Laboratory Medicine, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Xinhua Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
Li XuSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Yi WuClinical Research Center, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.
Shufan CaiClinical Research Center, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.
Lijun YeClinical Research Center, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.
Xiangxin HuangClinical Research Center, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.
Lin WangClinical Research Center, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.
Ying WangClinical Research Center, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.

Funding

Education Department Foundation of Zhejiang Province Y202044779Key Research and Development Program of Zhejiang Province WKJ-ZJ-1914National Natural Science Foundation of China 81971172Natural Science Foundation of Zhejiang Province LR21H090001
6 · The paper itself

Abstract

To evaluate the bioequivalence and safety of a generic ibuprofen arginine formulation (T) compared to Sibide (R) in healthy Chinese subjects under fed conditions, a randomized, open-label, single-dose, two-period, two-sequence crossover study was conducted. Twenty-eight eligible healthy subjects received a single 400 mg dose of either the T or R formulation following a standardized high-fat meal, with a 3-day washout period between doses. Plasma ibuprofen concentrations were quantified using a validated LC-MS/MS method. Pharmacokinetic parameters, including C

Indexed as

Anti-Inflammatory Agents, Non-SteroidalArginineDrugs, GenericIbuprofenAdultArea Under CurveChinaCross-Over StudiesDrug CombinationsEast Asian PeopleFemaleHealthy VolunteersHumansMaleTandem Mass SpectrometryTherapeutic EquivalencyAnti-Inflammatory Agents, Non-SteroidalArginineDrug CombinationsDrugs, GenericIbuprofenibuprofen argininefedibuprofen argininepharmacokineticssafety

Identifiers

PMID42605530
PMCPMC13478874

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.