ArticleClinical, cosmetic and investigational dermatology2026
Screening of Metabolic Reprogramming-Related Diagnostic Biomarkers and Analysis of Immune Heterogeneity in Atopic Dermatitis Based on Multi-Cohort Validation.
Article in Clinical, cosmetic and investigational dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Atopic dermatitis (AD), often called eczema, is a long-lasting skin condition that causes severe itching and distress for many people. While we know it involves the immune system and the skin barrier, we still do not fully understand how changes in how skin cells process energy affect the disease. We wanted to look into these energy processes to find better ways to help people living with eczema and see how their experiences differ from people with other skin conditions like psoriasis. Methods: We gathered and analyzed genetic data shared by patients and healthy volunteers across multiple study groups. Instead of looking at thousands of genes at once, we focused on groups of genes that metabolic reprogramming-related. We used computer models to see if specific genes could help identify people with eczema. We also studied how these genes relate to the immune cells present in the skin, and used this information to see if we could group patients into different molecular types. Results: We discovered two specific genes, called Conclusion: This study identifies
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