ArticlemicroPublication biology2026
Biotin Availability Modulates Transglutaminase Expression and Activity during Lipid Accumulation in 3T3-F442A Adipocytes.
Article in microPublication biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biotin deficiency impairs lipid accumulation in 3T3-F442A adipocytes despite allowing adipocyte differentiation. Here, we examined whether transglutaminase, a cytoskeletal remodeling enzyme associated with lipid droplets, is affected by biotin availability. Under biotin-deficient conditions, adipocytes showed reduced lipid droplet formation, cytoplasmic empty vesicle-like structures, and decreased transglutaminase expression and activity. Pharmacological inhibition of transglutaminase reduced lipid accumulation and decreased malic enzyme activity, suggesting a link between transglutaminase activity and NADPH-dependent lipogenesis. These findings identify transglutaminase as a biotin-sensitive component associated with lipid accumulation in 3T3-F442A adipocytes.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.