ArticleResearch and reports in urology2026
Metastatic Prostate Cancer: Impact of Site on Oncological Outcomes in Japanese Patients.
Article in Research and reports in urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: To investigate the site of metastasis and progression to castration-resistant prostate cancer (CRPC) following treatment of patients with metastatic prostate cancer who were diagnosed and treated at our hospital. Methods: We retrospectively examined the metastasis status and treatment response of patients with metastatic prostate cancer who were histologically diagnosed between the opening of our hospital in June 2015 and March 2025. Results: A total of 139 patients with metastatic prostate cancer visited our hospital and were diagnosed with the condition. CRPC-free survival was significantly correlated with the bone metastasis volume (EOD 0 and 1 vs EOD 2 to 4) (P = 0.0000477), volume categories (P = 0.00196), risk categories (P = 0.00231), and PSA levels below/not below 0.2 ng/mL following ADT (P = 4.18 × 10 Discussion and conclusion: In our data on patients with metastatic prostate cancer, factors influencing the prognosis were: the extent of bone metastasis and responsiveness of PSA levels to initial treatments such as ADT. Factors such as GG at the time of biopsy or presence of lung metastases did not significantly impact the prognosis. Our data suggest that patients with lung metastases, but without bone metastases, may have a relatively favorable prognosis. New prognostic evaluation indicators are needed.
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