Evidence map›Paper›PMID 42605277›Full record

ArticleNeuroethics2026

Digital Life Models and Transformative Choices: Could AI Simulations of Individual Minds (AI SIMs) Help us Make Important Life Decisions More Rationally and Authentically?

Christopher Register, Sebastian Porsdam Mann, Cristina Voinea, Julian Koplin, Julian Savulescu, Brian D Earp

Abstract read
In one paragraph

Article in Neuroethics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christopher RegisterUehiro Oxford Institute, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-5957-6376
Sebastian Porsdam MannCenter for Advanced Studies in Bioscience Innovation Law, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-1867-2097
Cristina VoineaUehiro Oxford Institute, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-4654-0697
Julian KoplinMonash Bioethics Centre, Monash University, Melbourne, Australia.ORCID 0000-0002-2752-7334
Julian SavulescuUehiro Oxford Institute, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-1691-6403
Brian D EarpCentre for Biomedical Ethics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0001-9691-2888

Funding

Wellcome Trust
6 · The paper itself

Abstract

The article advances the idea of "digital life models" to assist with difficult personal decisions, including those that can change an individual in profound ways. We propose that if personalized AI simulations can model how an individual's life might unfold under different conditions, this could help the individual better understand the likelihoods and expected subjective value of these possible outcomes. It remains to be seen whether these digital life models are technically feasible, given fundamental challenges in modeling psychological complexity, person-environment interactions, and value change. Ethical concerns include data privacy, cultural bias, and the risk of improperly shaping user decisions. Acknowledging these limitations, we argue that digital life models, if successfully developed, could in principle enhance rational and authentic decision-making in the face of potentially transformative change.

Indexed as

AI SIMsDigital life modelPersonal forecastingTransformative choices

Identifiers

PMID42605277
PMCPMC13477459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.