Evidence map›Paper›PMID 42605263›Full record

ArticleClinical and translational medicine2026

ROS-ATM-CBP axis-mediated PARP1 lactylation aggravates doxorubicin-induced cardiotoxicity.

Wenbin Wang, Yingxian Sun

Abstract read
In one paragraph

Article in Clinical and translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Wenbin WangDepartment of Cardiology, First Hospital of China Medical University, Shenyang, China.
Yingxian SunDepartment of Cardiology, First Hospital of China Medical University, Shenyang, China.

Funding

National Natural Science Foundation of China 82171572
6 · The paper itself

Abstract

Doxorubicin (DOX) is a potent antineoplastic agent, but its clinical application is limited by the life-threatening cardiotoxic effects. Poly(ADP-ribose) polymerase 1 (PARP1) transfers ADP-ribose groups from donor NAD

Indexed as

Ataxia Telangiectasia Mutated ProteinsCardiotoxicityDoxorubicinPoly (ADP-Ribose) Polymerase-1Reactive Oxygen SpeciesAnimalsApoptosisMiceMice, KnockoutOxidative StressSignal TransductionAtaxia Telangiectasia Mutated ProteinsAtm protein, mouseDoxorubicinParp1 protein, mousePoly (ADP-Ribose) Polymerase-1Reactive Oxygen SpeciescardiotoxicityCBPdoxorubicinlactylationPARP1ROS

Identifiers

PMID42605263
PMCPMC13478851

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.