ReviewCNS neuroscience & therapeutics2026
Exercise and Circadian Rhythm Regulation: Mechanisms, Resilience, and Therapeutic Potential for Neurological Diseases.
Review in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Authors and funding
5 authors.
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Abstract
backgroundCircadian rhythms regulate sleep-wake cycles, hormonal secretion, metabolism, and immune responses. Disruption of these rhythms is linked to the onset and progression of various neurological diseases. Emerging evidence suggests that exercise, a non-photic zeitgeber, can modulate circadian function at both central and peripheral levels by regulating core clock gene expression, synchronizing hormonal and metabolic rhythms, and reducing neuroinflammation. Through these mechanisms, exercise enhances the amplitude, stability, and phase alignment of circadian rhythms and may promote physiological resilience. REVIEW: This review summarizes the molecular and systemic mechanisms through which exercise supports circadian homeostasis and discusses their relevance to stroke and Alzheimer's disease. In both conditions, circadian misalignment contributes to pathological processes including oxidative stress, neuroinflammation, and impaired neurovascular repair. By restoring circadian alignment, appropriately timed exercise may improve neurological outcomes through effects on neuroplasticity, immune regulation, and metabolic synchronization. SUMMARY: Taken together, current evidence may suggest that exercise can be a promising non-pharmacological strategy to enhance circadian resilience, reduce disease vulnerability, and support neurological recovery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.