Evidence map›Paper›PMID 42604923›Full record

ArticleBMC biology2026

Genome-wide integrative dissection of genetic basis of fiber color and whiteness regulation in upland cotton (Gossypium hirsutum).

Shiguftah Khalid, Zhenzhen Wang, Tahir Mahmood, Xiaoli Geng, Hongge Li, Xiaomeng Zhang, Shoupu He, Xiongming Du

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shiguftah Khalid *State Key Laboratory of Cotton Bio-Breeding and Integrated Utilization, Institute of Cotton Research, Chinese Academy of Agricultural Sciences, Anyang, 455000, China.
Zhenzhen Wang *State Key Laboratory of Cotton Bio-Breeding and Integrated Utilization, Institute of Cotton Research, Chinese Academy of Agricultural Sciences, Anyang, 455000, China.
Tahir MahmoodState Key Laboratory of Cotton Bio-Breeding and Integrated Utilization, Institute of Cotton Research, Chinese Academy of Agricultural Sciences, Anyang, 455000, China.
Xiaoli GengState Key Laboratory of Cotton Bio-Breeding and Integrated Utilization, Institute of Cotton Research, Chinese Academy of Agricultural Sciences, Anyang, 455000, China.
Hongge LiState Key Laboratory of Cotton Bio-Breeding and Integrated Utilization, Institute of Cotton Research, Chinese Academy of Agricultural Sciences, Anyang, 455000, China.
Xiaomeng ZhangState Key Laboratory of Cotton Bio-Breeding and Integrated Utilization, Institute of Cotton Research, Chinese Academy of Agricultural Sciences, Anyang, 455000, China.
Shoupu HeState Key Laboratory of Cotton Bio-Breeding and Integrated Utilization, Institute of Cotton Research, Chinese Academy of Agricultural Sciences, Anyang, 455000, China. heshoupu@caas.cn.
Xiongming DuState Key Laboratory of Cotton Bio-Breeding and Integrated Utilization, Institute of Cotton Research, Chinese Academy of Agricultural Sciences, Anyang, 455000, China. duxiongming@caas.cn.ORCID 0000-0001-8431-5592

Funding

This work was supported by a grant from National Key Research and Development Program of China (2022YFD1200300). The authors also appreciate the National Cotton Germplasm Mid-term bank (Anyang) for providing the cotton germplasm seeds 2022YFD1200300
6 · The paper itself

Abstract

backgroundNaturally colored cotton has gained renewed interest due to increasing environmental concerns over synthetic dyes. The genetic regulatory characteristics of fiber color are discovered by two perspectives in this study.

resultsGenome-wide association studies (GWAS) identified two major loci D11: 24.3-24.7 Mb and A07: 20.4-22.3 Mb controlling fiber color variation. Integrative QTL mapping and transcriptome profiling revealed three candidate genes Gh_D11G208100, Gh_D11G207100, and Gh_D11G207600 with distinct expression profiles in fiber whiteness on D11. In contrast, the A07 locus harbors key transcription regulators TT2, C1, and bHLH82 which are implicated in flavonoid-mediated brown pigmentation along with differentially expressed genes, Gh_A07G015400, Gh_A07G019500, and Gh_A07G019400, further supporting their potential role in regulating fiber pigmentation. Segregation analysis of fiber color across three different F

conclusionsThis integrated analysis supports a model of coordinated regulation, where transcriptional control from A07 influences pigment biosynthesis, while D11 modulates fiber surface or secondary metabolism to fine tune color intensity and whiteness.

Indexed as

Cotton FiberGenome, PlantGossypiumPigmentationChromosome MappingGene Expression ProfilingGene Expression Regulation, PlantGenes, PlantGenome-Wide Association StudyPhenotypeQuantitative Trait LociColored cottonFiber qualityFlavonoid pathwayGenome-wide associationInheritance patterns

Identifiers

PMID42604923
PMCPMC13480058

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.