Variation of Arene Moiety in Ruthenium (II) Arene Halido Complexes of Quinoline and Benzazole-Derived Ligands: Development and Antiprostate Cancer Potential.

Tanveer A Khan, Anubha Yadav, Priyal Malpani, Kishalay Bhar, Vinit Kumar, Anuj K Sharma

Abstract read

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Article in Chemistry, an Asian journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Tanveer A KhanDepartment of Chemistry, Central University of Rajasthan, Ajmer, India.ORCID 0000-0001-6724-6310

Anubha YadavAmity Institute of Molecular Medicine and Stem Cell Research, Amity University, Noida, Uttar Pradesh, India.ORCID 0009-0000-7856-5739

Priyal MalpaniDepartment of Chemistry, Central University of Rajasthan, Ajmer, India.ORCID 0000-0002-2112-4980

Kishalay BharDepartment of Chemistry, Central University of Rajasthan, Ajmer, India.ORCID 0000-0003-3086-6190

Vinit KumarAmity Institute of Molecular Medicine and Stem Cell Research, Amity University, Noida, Uttar Pradesh, India.ORCID 0000-0003-4351-6253

Anuj K SharmaDepartment of Chemistry, Central University of Rajasthan, Ajmer, India.ORCID 0000-0002-5090-3713

Funding

Council of Scientific and Industrial Research, India 09/1131(23161)/2025-EMR-IDepartment of Science and Technology, Ministry of Science and Technology, India SR/FST/CSI-257/2014(C)Ministry of Education MoE/STARS/2023-0529Science and Engineering Research Board CRG/2022/004355

6 · The paper itself

Abstract

Castration-resistant prostate cancer (CRPC) is an advanced, treatment-refractory disease with high mortality and limited therapeutic options, necessitating novel metallodrugs with enhanced potency and reduced toxicity. Herein, we report the design and syntheses of two quinoline-benzazole hybrid bidentate ligands-2-(1H-benzo[d]imidazol-2-yl)quinoline (L1) and 2-(quinolin-2-yl)benzo[d]thiazol (L2)-along with four new half-sandwich ruthenium(II) arene chlorido complexes of the general formula [(η

Indexed as

Antineoplastic AgentsCoordination ComplexesQuinolinesRutheniumApoptosisCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansLigandsMaleMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsCoordination ComplexesLigandsquinolineQuinolinesRutheniumCOSY‐NMRcytotoxicityDNA bindingprostate cancerRu(II) (arene) halido complexes

Identifiers

PMID42604829

DOI10.1002/asia.70946

PMCPMC13477996

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.