ArticleJournal of clinical periodontology2026
Childhood Famine Exposure and Late-Life Edentulism: Evidence From Natural Experiments.
Article in Journal of clinical periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo examine whether childhood famine exposure affects late-life edentulism using natural experiments from Asia, Europe and America. MATERIALS AND
methodsWe utilised historical famines as exogenous shocks. Data were pooled from 10 population-based studies across eight countries (165,586 participants). Because the famine-exposed cohort is older at survey than the comparison cohort, we separated famine exposure from the birth-cohort age gradient using a regression discontinuity in time, an interrupted time series, a region-of-birth famine-intensity difference-in-differences, a pre-famine comparison cohort and applied negative controls.
resultsThe crude positive association (risk ratio [RR] 1.69) was eliminated after adjustment for current age (RR 1.07, 95% confidence interval (CI) 0.92-1.23), and the famine cohort did not differ from the older pre-famine cohort (RR 0.97). The regression discontinuity (+0.13% points, 95% CI: -1.50 to +1.77), interrupted time series (-4.01% points, p = 0.15) and the region-of-birth difference-in-differences in the two Chinese cohorts (unadjusted, both p ≥ 0.07) were null, as were all negative controls.
conclusionsOnce the birth-cohort age gradient is accounted for, childhood famine exposure shows no detectable effect on late-life edentulism; the crude positive association is largely explained by age confounding, which cross-sectional famine-cohort comparisons do not address.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.