Evidence map›Paper›PMID 42604473›Full record

ArticleLung2026

Fatigue, Muscular Performance, and Quadriceps Fiber Type Profile in Lymphangioleiomyomatosis and Healthy Matched Controls.

Mary Beth Brown, Claire E Child, Paul Kim, Morgan L Kelly, Sophia Arons, Haotian D Cai, Kevin J McQuade, Ylinne T Lynch, Lawrence A Ho, Luis F Gonzalez-Cuyar

Abstract read
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In one paragraph

Article in Lung, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mary Beth BrownDepartment of Rehabilitation Medicine, Division of Physical Therapy, University of Washington, Health Sciences Building BB-826, 1607 NE Pacific St, Seattle, WA, 98195, USA. mbbrown1@uw.edu.ORCID http://orcid.org/0000-0003-4229-6877
Claire E ChildDepartment of Rehabilitation Medicine, Division of Physical Therapy, University of Washington, Health Sciences Building BB-826, 1607 NE Pacific St, Seattle, WA, 98195, USA.
Paul KimDepartment of Rehabilitation Medicine, Division of Physical Therapy, University of Washington, Health Sciences Building BB-826, 1607 NE Pacific St, Seattle, WA, 98195, USA.
Morgan L KellyDepartment of Rehabilitation Medicine, Division of Physical Therapy, University of Washington, Health Sciences Building BB-826, 1607 NE Pacific St, Seattle, WA, 98195, USA.
Sophia AronsDepartment of Rehabilitation Medicine, Division of Physical Therapy, University of Washington, Health Sciences Building BB-826, 1607 NE Pacific St, Seattle, WA, 98195, USA.
Haotian D CaiDepartment of Rehabilitation Medicine, Division of Physical Therapy, University of Washington, Health Sciences Building BB-826, 1607 NE Pacific St, Seattle, WA, 98195, USA.
Kevin J McQuadeDepartment of Rehabilitation Medicine, Division of Physical Therapy, University of Washington, Health Sciences Building BB-826, 1607 NE Pacific St, Seattle, WA, 98195, USA.
Ylinne T LynchDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, USA.
Lawrence A HoDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, USA.
Luis F Gonzalez-CuyarDepartment of Laboratory Medicine and Pathology, Division of Neuropathology, University of Washington, Seattle, USA.

Funding

The LAM Foundation LAM0130PB07-18
6 · The paper itself

Abstract

purposeFatigue is a common symptom in lymphangioleiomyomatosis (LAM) and is associated with reduced physical activity and quality of life. Coexistent skeletal muscle dysfunction has been reported for other chronic lung diseases but has not been investigated in LAM.

methodsFifteen patients with LAM and 15 matched individuals without LAM (NL) underwent computerized lower extremity dynamometry, standardized functional tests, and fatigue surveys. Immunohistochemistry to detect LAM+ cells and to characterize fiber-type distribution was performed on vastus lateralis (VL) samples of LAM and NL. Maximal cardiopulmonary exercise test (CPET) and six-minute walk test (6MWT) were additionally conducted for LAM. Welch's t-testing compared measures between LAM and NL. Pearson correlation tested relationships between variables. Data are mean ± SD.

resultsLAM exhibited lower (p < 0.05) muscular force (by 220 ± 89 N), power (by 312 ± 129 W), and endurance (by 4674 ± 1974 N*sec) in dynamometry and functional tests (by 119 ± 45s in wall squat test), and worse fatigue survey scores (p = 0.02 to 0.0004). Poorer muscular endurance in LAM was associated with less distance achieved in 6MWT (r = 0.68), lower VO

conclusionMuscular endurance and strength is lower in LAM, coincident with greater self-reported fatigue. Fiber type shift reported for skeletal muscle in other chronic lung disease is not observed in LAM. Further work is needed to elucidate peripheral muscle mechanisms for fatigue and exercise intolerance in LAM.

Indexed as

FatigueLymphangioleiomyomatosisMuscle FatigueMuscle StrengthQuadriceps MuscleAdultCase-Control StudiesExercise TestExercise ToleranceFemaleHumansMaleMiddle AgedMuscle Fibers, Fast-TwitchMuscle Fibers, Slow-TwitchMuscle Strength DynamometerFiber typingLAMLower extremity dynamometryLymphangioleiomyomatosisMuscle biopsyMuscular performanceSkeletal muscle

Identifiers

PMID42604473
PMCPMC13478029

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.