ArticleArchives of Iranian medicine2026
Risk Factors of Incidental Cholangiocarcinoma in Primary Sclerosing Cholangitis: A Cross-Sectional Study with ROC Curve Analysis.
Article in Archives of Iranian medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCholangiocarcinoma (CCA) is the most common malignancy in patients with primary sclerosing cholangitis (PSC). It is typically associated with low survival rates due to late diagnosis. This study aimed to evaluate the predictors of incidental CCA in PSC patients.
methodsIn this cross-sectional study, we included 425 patients aged 18 years or older who underwent liver transplant with a confirmed diagnosis of PSC. Demographic data, pre-transplant clinical features, and para-clinical evidence were obtained from medical records. Pathology experts examined livers removed during transplantation, and CCA was diagnosed accordingly. Multivariable logistic regression and receiver operating characteristic (ROC) curve analyses were conducted to assess the risk factors for incidental CCA and the effectiveness of carbohydrate antigen 19-9 (CA 19‒9) in predicting CCA, respectively.
resultsOf the 425 included patients, 29 had PSC-CCA and 396 patients had PSC alone. According to the multivariable logistic model, CA 19‒9 (odds ratio [OR]=1.001, 95% confidence interval [CI]: 1.000‒1.001,
conclusionWe found that CA 19‒9 and weight loss are independent predictors of incidental CCA in PSC patients, and a CA 19‒9 level above 46 U/mL has relatively good predictive power for incidental CCA.
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