Evidence map›Paper›PMID 42604416›Full record

ArticleArchives of Iranian medicine2026

Hypomethylation of the Human

Delnya Gholami, Zahra Ourang, Mohammad Saatchi, Esmat Rigi Yousefabadi, Emran Esmaeilzadeh, Masoumeh Akhlaghi, Hoda Kavosi, Hamid Reza Khorram Khorshid

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In one paragraph

Article in Archives of Iranian medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Delnya GholamiGenetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.ORCID 0000-0003-4762-0859
Zahra OurangRheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad SaatchiPersonalized Medicine and Genometabolomics Research Center, Hope Generation Foundation, Tehran, Iran.
Esmat Rigi YousefabadiGenetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Emran EsmaeilzadehFetal Health Research Center, Hope Generation Foundation, Tehran, Iran.
Masoumeh AkhlaghiRheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Hoda KavosiRheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Hamid Reza Khorram KhorshidGenetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.ORCID 0000-0003-0357-1573

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGiven the pivotal role of DNA methylation in the progression and severity of rheumatoid arthritis (RA), identifying a unique methylation pattern associated with the disease could support early detection, disease monitoring, and the development of personalized treatment plans. We aimed to explore the potential of

methodsWe collected 105 peripheral blood specimens from RA patients and 110 from healthy subjects. We then performed methylation analysis using the methylation-quantification of endonuclease-resistant DNA (MethyQESD) technique. Finally, we analyzed the data using appropriate nonparametric tests.

resultsOur study revealed a significant decrease in

conclusionThe methylation levels of

Indexed as

2',5'-Oligoadenylate SynthetaseArthritis, RheumatoidDNA MethylationAdultBiomarkersCase-Control StudiesFemaleHumansIranMaleMiddle AgedROC Curve2',5'-Oligoadenylate SynthetaseBiomarkersOAS2 protein, humanArthritisDNA methylationEpigeneticsRheumatoid

Identifiers

PMID42604416
PMCPMC13338500

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.