Trial reportJournal of pain research2026
Effect of Adding Erector Spinae Plane Block to a Multimodal Analgesic Regimen on Quality of Recovery After Laparoscopic Colon Cancer Surgery: A Prospective Randomized Controlled Trial.
Trial report in Journal of pain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Background: Available evidence regarding the effect of erector spinae plane block (ESPB) as a component of multimodal analgesia on postoperative quality of recovery after laparoscopic colon cancer surgery remains inconsistent. Purpose: This trial aimed to determine whether adding single-shot bilateral ESPB to a multimodal analgesic regimen would improve early postoperative quality of recovery. Methods: In this prospective, randomized, outcome-assessor-blinded controlled trial, 60 participants undergoing laparoscopic radical resection of colon cancer under general anesthesia were randomly assigned (1:1) to receive the ultrasound-guided bilateral single-shot ESPB at the T12 level with 20 mL of 0.25% ropivacaine on each side or a sham procedure before anesthesia induction. The primary outcome was the QoR-15 score at 24 h postoperatively. Secondary outcomes included mean intraoperative remifentanil infusion rate, postoperative sufentanil consumption, postoperative pain scores, time to first patient-controlled intravenous analgesia demand, time to first ambulation, time to first flatus, adverse events, and patient satisfaction. Results: Five participants were excluded after randomization; therefore, data from 55 participants were included in the per-protocol analysis. The adjusted mean QoR-15 score at 24 h postoperatively was 126.2 in the ESPB group and 120.3 in the control group, with an adjusted mean difference of 5.88 points (95% confidence interval, 4.02-7.74; p<0.001). Compared with the control group, the ESPB group had a lower intraoperative remifentanil use (p<0.001) and a shorter time to first ambulation (p=0.007). No significant between-group differences were observed in other secondary outcomes. Conclusion: Adding single-shot bilateral ESPB to a multimodal analgesic regimen was associated with an improved quality of early postoperative recovery, a lower intraoperative remifentanil use and earlier ambulation in patients undergoing laparoscopic colon cancer surgery. Larger multicenter studies are warranted to confirm these findings. Trial Registration: Chinese Clinical Trial Registry, ChiCTR2300073180; date of registration: July 4, 2023.
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