Evidence map›Paper›PMID 42604351›Full record

ArticleJTCVS open2026

Use of whole blood in pediatric congenital heart surgery.

Laura Maitoza, Stephanie Bland, Precious Ann Fortes, Andrea McGonigle, Tiffany Williams, Glen Van Arsdell, Myke Federman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JTCVS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Laura MaitozaDepartment of Pediatrics, Mattel Children's Hospital, University of California Los Angeles, Los Angeles, Calif.
Stephanie BlandDepartment of Cardiac Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, Calif.
Precious Ann FortesWing-Kwai and Alice Lee-Tsing Chung Transfusion Service, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif.
Andrea McGonigleWing-Kwai and Alice Lee-Tsing Chung Transfusion Service, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif.
Tiffany WilliamsDepartment of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, Calif.
Glen Van ArsdellDepartment of Cardiac Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, Calif.
Myke FedermanDepartment of Pediatrics, Mattel Children's Hospital, University of California Los Angeles, Los Angeles, Calif.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Cardiopulmonary bypass is necessary for surgical repair of complex congenital heart disease. We studied whether whole blood use in circuit prime and for initial intraoperative transfusion needs improved postoperative outcomes in infants less than 2 months of age. Methods: This was a single-center retrospective chart review of infants who underwent cardiac surgery using cardiopulmonary bypass between May 2019 and February 2023. We reviewed and analyzed intraoperative and postoperative variables for whole blood and standard blood prime use in patients, whereas the remainder of clinical management stayed unchanged. Results: Ninety-five patients were included in our analysis. Donor exposure was reduced in the whole blood group with a median of 3 donors (Q1-Q3: 2-4) compared with the standard group with 5 donors (Q1-Q3: 5-6, Conclusions: The whole blood cohort was found to have fewer donor exposures and less intraoperative individual blood component use but no difference in postoperative outcomes. Continued research must be pursued to understand if whole blood with new circuit techniques and hemostatic interventions can reduce transfusion needs and lead to superior results.

Indexed as

cardiac surgerycardiopulmonary bypasscongenital heart diseasewhole blood

Identifiers

PMID42604351
PMCPMC13477141

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.