Evidence map›Paper›PMID 42604349›Full record

ArticlePharmacogenomics and personalized medicine2026

Implementing Pharmacogenomics in Contemporary Hospital Care: Insights from Multidisciplinary Knowledge Exchange.

Safeera Y Hussainy, Rachel Conyers, Paul A James, Marliese Alexander, Claire Moore, Susan Fisher, Michelle Gerstman, Aaron K Wong, Stephanie Chau, Amy Clarke and 3 more

Abstract read
In one paragraph

Article in Pharmacogenomics and personalized medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Safeera Y HussainyPharmacy Department, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Rachel ConyersDepartment of Paediatrics, University of Melbourne, Melbourne, VIC, Australia.
Paul A JamesParkville Familial Cancer Centre, Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Marliese AlexanderPharmacy Department, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Claire MooreDepartment of Paediatrics, University of Melbourne, Melbourne, VIC, Australia.
Susan FisherPharmacy Department, Melbourne Health, Melbourne, VIC, Australia.
Michelle GerstmanSir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.
Aaron K WongSir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.ORCID 0000-0002-6507-1219
Stephanie ChauEMR Optimisation Department, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.ORCID 0009-0009-4458-9797
Amy ClarkeMelbourne Genomics Health Alliance, Melbourne, VIC, Australia.
Jennifer PhilipDepartment of Medicine, University of Melbourne, Melbourne, VIC, Australia.ORCID 0000-0002-3312-0645
Carl M J KirkpatrickMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.
Senthil LingaratnamPharmacy Department, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.ORCID 0000-0003-2678-5208

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pharmacogenomics (PGx) is increasingly recognised as a cornerstone of personalised medicine, with established recommendations for many commonly prescribed medicines. Despite this, translation into real-world clinical practice remains inconsistent, reflecting persistent implementation and health-system gaps. Objective: To provide a multidisciplinary perspective on the system-level conditions required to normalise PGx within contemporary hospital care, drawing on structured knowledge exchange and priority-setting across clinical, digital and governance domains. Methods: A multidisciplinary knowledge exchange program convened clinicians, pharmacists, genetic services, informatics teams, researchers and health-service leaders across oncology, transplantation, peri-operative care and palliative care. Knowledge was exchanged through presentations, informing the generation and ranking of shared priorities in groups and individually using the Nominal Group Technique. Aggregate scores were calculated, and priorities further refined. Presentation insights were synthesised using a narrative, interpretive approach, to identify cross-cutting translational themes. Results: Eleven shared priorities were identified across four broad critical levers for sustainable integration: (1) computable, reusable PGx data embedded within electronic medical records (EMR); (2) coordinated and equitable testing and prescribing pathways; (3) workforce capability and stewardship; and (4) governance. Equity, access and data sovereignty were highlighted as foundational to responsible scale-up, particularly for First Nations peoples and under-represented communities. Conclusion: Insights from this knowledge-exchange program highlight the feasibility and clinical relevance of PGx, and identify workforce capability, EMR integration, and system-level governance as critical implementation levers of adoption. Coordinated national investment and policy alignment will be central to realising the full value of PGx.

Indexed as

clinical implementationelectronic medical recordshealth-systems integrationpharmacogenomics

Identifiers

PMID42604349
PMCPMC13477175

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.