Evidence map›Paper›PMID 42604348›Full record

ArticleJTCVS open2026

Early experience using quantitative guidelines for aortic valve repair in pediatric patients.

Lauren E Marshall, Dominic P Recco, Kimberlee Gauvreau, Breanna Piekarski, Kandice Mah, Luis G Quinonez, Michael H Kwon, Sitaram M Emani, Pedro J Del Nido, Christopher W Baird and 2 more

Abstract read
In one paragraph

Article in JTCVS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lauren E MarshallDepartment of Cardiac Surgery, Boston Children's Hospital, Boston, Mass.
Dominic P ReccoDepartment of Cardiac Surgery, Boston Children's Hospital, Boston, Mass.
Kimberlee GauvreauDepartment of Cardiology, Boston Children's Hospital, Boston, Mass.
Breanna PiekarskiDepartment of Cardiac Surgery, Boston Children's Hospital, Boston, Mass.
Kandice MahDepartment of Cardiology, Boston Children's Hospital, Boston, Mass.
Luis G QuinonezDepartment of Cardiac Surgery, Boston Children's Hospital, Boston, Mass.
Michael H KwonDepartment of Cardiac Surgery, Boston Children's Hospital, Boston, Mass.
Sitaram M EmaniDepartment of Cardiac Surgery, Boston Children's Hospital, Boston, Mass.
Pedro J Del NidoDepartment of Cardiac Surgery, Boston Children's Hospital, Boston, Mass.
Christopher W BairdDepartment of Cardiac Surgery, Boston Children's Hospital, Boston, Mass.
David M HogansonDepartment of Cardiac Surgery, Boston Children's Hospital, Boston, Mass.
Peter E HammerDepartment of Cardiac Surgery, Boston Children's Hospital, Boston, Mass.

Funding

Pediatric Surgeon-Scientist Training Program in Vascular DiseasesT32HD104582 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Joyce E. Bischoff, Arin K. Greene · 2022 to 2026
$1.1M
NICHD NIH HHS T32 HD104582
6 · The paper itself

Abstract

Objective: Pediatric aortic valve repair has traditionally been guided by qualitative assessment. In this study, we present our early experience using quantitative guidelines to inform repair. Methods: We present a simple model of normal aortic valve proportions and compare outcomes of valves repaired with and without model-based guidelines. In a secondary analysis of a subset of valves that preoperatively exhibited 2 or 3 distinct leaflets with normal commissures, we assess whether achieving target normal leaflet free edge lengths is associated with less regurgitation. Results: Valve repair aided by modeling exhibited similar rates of aortic regurgitation (AR) and aortic stenosis (AS) on discharge and follow-up echocardiograms to controls. The repair versus replacement rate increased significantly from 57% in controls to 71% during the period in which modeling was used ( Conclusions: Use of quantitative repair guidelines achieved similar outcomes and higher repair rates despite higher preoperative valve complexity. Among valves with distinct leaflets and normal commissures, changes in AR from preoperation to postoperation closely tracked surgical changes to relative leaflet free edge length. Although initial results are promising, larger numbers and longer follow-up are needed.

Indexed as

aortic valve repairbicuspidizationcardiovascular surgeryleaflet free edge

Identifiers

PMID42604348
PMCPMC13477138

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.