Evidence map›Paper›PMID 42604345›Full record

ArticleJTCVS open2026

A novel dual-orifice mitral bioprosthesis: Proof-of-concept in an ovine model.

Jinmiao Chen, Xiaojie Gu, Lai Wei, Sun Pan, Huan Liu, Krzysztof Bartus, Nianwei Zhou, Shengzhang Wang, Tao Hong, Chunsheng Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JTCVS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jinmiao ChenDepartment of Cardiovascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Xiaojie GuInstitute of Biomechanics, College of Biomedical Engineering, Fudan University, Shanghai, China.
Lai WeiDepartment of Cardiovascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Sun PanDepartment of Cardiovascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Huan LiuDepartment of Cardiovascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Krzysztof BartusDepartment of Cardiovascular Surgery and Transplantology, Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland.
Nianwei ZhouDepartment of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai, China.
Shengzhang WangInstitute of Biomechanics, College of Biomedical Engineering, Fudan University, Shanghai, China.
Tao HongDepartment of Cardiovascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Chunsheng WangDepartment of Cardiovascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Conventional large mitral bioprostheses may cause left ventricular outflow tract obstruction. A dual-orifice mitral bioprosthesis was designed for both surgical and transcatheter valve replacement. Methods: Pulsatile flow testing was used to measure the effective orifice area (EOA). Computational fluid dynamics analysis was conducted to assess thrombogenic and hemolysis risk. An ovine model was used to evaluate procedural safety, hemodynamic performance, and leaflet calcification. Results: Pulsatile flow testing showed that the EOAs of surgical dual-orifice valve (17K, 18K, 19K, 20K, 21K) were 2.0 ± 0.2, 2.1 ± 0.3, 2.4 ± 0.4, 2.5 ± 0.1, and 2.7 ± 0.3 cm Conclusions: The dual-orifice mitral bioprosthesis may represent an alternative design for mitral valve replacement, especially for patients with large mitral annuli. This findings also show the potential of this design in transcatheter mitral valve replacement.

Indexed as

dual-orifice mitral bioprosthesisleft ventricular outflow tract obstructionsurgical mitral valve replacementtranscatheter mitral valve replacement

Identifiers

PMID42604345
PMCPMC13477137

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.