Evidence map›Paper›PMID 42604308›Full record

ArticleJTCVS open2026

Cerebral protection in extended arch repair for acute type A aortic dissection.

Lauren A Gillinov, Mikolaj Berezowski, Alexandra E Sperry, James Lao, Daniel Bazianos, Michael A Catalano, Kendall M Lawrence, Wilson Y Szeto, Nimesh D Desai

Abstract read
In one paragraph

Article in JTCVS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lauren A GillinovDivision of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pa.
Mikolaj BerezowskiDivision of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pa.
Alexandra E SperryDivision of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pa.
James LaoDivision of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pa.
Daniel BazianosDivision of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pa.
Michael A CatalanoDivision of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pa.
Kendall M LawrenceDivision of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pa.
Wilson Y SzetoDivision of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pa.
Nimesh D DesaiDivision of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the association between cerebral perfusion strategy and neurologic outcomes following extended arch repair for acute type A aortic dissection (ATAAD). Methods: We identified patients who underwent extended arch repair for ATAAD at our institution between 2002 and 2024. Patients were stratified by cerebral perfusion strategyL antergrade certebral perfusion (ACP) or retrograde cerebral perfusion (RCP). Outcomes included stroke and a composite of 30-day mortality, stroke, and temporary neurologic dysfunction. Multivariable analysis was used to evaluate the association between cerebral perfusion strategy and the composite outcome. Results: A total of 206 patients met the study inclusion criteria (median age, 58.7 years; 25.2% female). ACP was the most common cerebral perfusion strategy (58.7%; n = 121), followed by combined ACP and RCP (32.0%; n = 66) and then RCP (9.2%; n = 19). The median circulatory arrest time was longer in cases using combined ACP and RCP (62 minutes) compared to ACP (38 minutes) or RCP (34 minutes) ( Conclusions: Despite prolonged circulatory arrest times, cases using combined ACP and RCP were not associated with an increased rate of stroke. The combined approach may help extend the safe duration of circulatory arrest in extended arch repair for ATAAD.

Indexed as

acute type A aortic dissectioncerebral perfusioncirculatory arrest

Identifiers

PMID42604308
PMCPMC13477021

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.