Evidence map›Paper›PMID 42604287›Full record

ArticleJTCVS open2026

Outcomes of surgical and transcatheter aortic valve replacement in patients with large and extra-large aortic annuli.

Xander Jacquemyn, Justin C Wang, Dustin Kliner, Derek Serna-Gallegos, Irsa Hasan, Takuya Ogami, Floyd Thoma, Yisi Wang, Catalin Toma, David West and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JTCVS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xander JacquemynUPMC Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa.
Justin C WangUPMC Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa.
Dustin KlinerUPMC Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa.
Derek Serna-GallegosUPMC Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa.
Irsa HasanUPMC Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa.
Takuya OgamiUPMC Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa.
Floyd ThomaUPMC Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa.
Yisi WangUPMC Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa.
Catalin TomaUPMC Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa.
David WestUPMC Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa.
Amber MakaniUPMC Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa.
Ibrahim SultanUPMC Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The study objective was to evaluate outcomes after aortic valve replacement in patients with large or extra-large annuli. Methods: We conducted a retrospective cohort study of adults undergoing isolated transcatheter aortic valve replacement or surgical aortic valve replacement from 2021 to 2025 at a single quaternary care center. Eligible patients had large (annular area ≥575 mm Results: A total of 414 patients underwent aortic valve replacement, including 353 transcatheter aortic valve replacements and 61 surgical aortic valve replacements. The median age was 78.8 years (interquartile range, 73.4-83.8), and 20 patients (4.8%) were female. Extra-large annuli were present in 109 patients (26%). Transcatheter aortic valve replacement recipients were older (median 80.2 vs 68.0 years, Conclusions: Aortic valve replacement in patients with large or extra-large annuli is safe, with low early mortality. Differences in long-term outcomes primarily reflect differences in baseline patient risk profiles rather than treatment strategy.

Indexed as

aortic valve replacementheart failurelarge aortic annulussurgical aortic valve replacementtranscatheter aortic valve replacement

Identifiers

PMID42604287
PMCPMC13477070

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.