The impact of minimally invasive mitral valve surgery on early postoperative organ dysfunction.

Objective: The use of a minimally invasive approach in mitral valve surgery is increasing; however, its impact on early organ dysfunction and hemodynamic support remains debated. This study compared postoperative organ dysfunction, assessed by the Sequential Organ Failure Assessment score and the maximum vasoactive-inotropic score at 24 hours, between the minimally invasive approach in mitral valve surgery and sternotomy. Methods: A retrospective analysis was performed of all consecutive patients undergoing mitral valve surgery at a single center. Patients were stratified according to surgical approach (minimally invasive approach in mitral valve surgery vs sternotomy). Primary outcomes were Sequential Organ Failure Assessment and maximum vasoactive-inotropic score at 24 hours. Group comparisons were performed using nonparametric tests, and multivariable regression models were adjusted for demographics and clinical covariates. A propensity score-matched sensitivity analysis was also performed. Results: A total of 710 patients were included, 275 undergoing the minimally invasive approach in mitral valve surgery and 435 undergoing sternotomy. Median Sequential Organ Failure Assessment at 24 hours was lower after the minimally invasive approach in mitral valve surgery (4 [interquartile range, 2-6] vs 5 [interquartile range, 3-9], Conclusions: In this large single-center cohort, the minimally invasive approach in mitral valve surgery was associated with lower early postoperative organ dysfunction and reduced vasoactive-inotropic support compared with sternotomy. These findings were consistent after multivariable adjustment and propensity score matching and support a more favorable early postoperative physiologic profile with a minimally invasive approach in mitral valve surgery.