Engineered GLUT1-targeted STING polyproagonists: Redox-triggered activation and enhanced endosomal escape for cancer immunotherapy.

Arsalan Raza, Anum Kayani, Guopu Huang, Cheng Li, Qinghao Zhou, Khurshed Bozorov, Yuanyuan Ji, Zhishen Ge

Abstract read

In one paragraph

Article in Asian journal of pharmaceutical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Arsalan RazaDepartment of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, China.

Anum KayaniDepartment of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, China.

Guopu HuangSchool of Chemistry, Xi'an Key Laboratory of Sustainable Polymer Materials, Xi'an Jiaotong University, Xi'an 710049, China.

Cheng LiDepartment of Geriatric General Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.

Qinghao ZhouSchool of Chemistry, Xi'an Key Laboratory of Sustainable Polymer Materials, Xi'an Jiaotong University, Xi'an 710049, China.

Khurshed BozorovDepartment of Organic Synthesis and Bioorganic Chemistry, Institute of Biochemistry, Samarkand State University, Samarkand 140104, Uzbekistan.

Yuanyuan JiDepartment of Geriatric General Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.

Zhishen GeSchool of Chemistry, Xi'an Key Laboratory of Sustainable Polymer Materials, Xi'an Jiaotong University, Xi'an 710049, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The stimulator of interferon genes (STING) pathway plays a critical role in bridging innate and adaptive antitumor immunity, representing a promising target in cancer immunotherapy. However, the clinical application of STING agonists is limited by poor pharmacokinetics, low cytosolic delivery efficiency, and immune-related adverse effects. To address these challenges, we developed STING polyproagonist nanoparticles (named GA+S@SR) by self-assembly of an amphiphilic diblock copolymer, P(OEGMA-

Indexed as

Endosomal escapeGLUT1-targetingImmunotherapyRedox-triggered activationSTING agonist

Identifiers

PMID42604134

DOI10.1016/j.ajps.2026.101186

PMCPMC13476619

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.